Molecular pathological analysis of the structure and expression of constituents of the p53 pathway is likely to have value in diagnosis, in prognostic assessment and, ultimately, in treatment of breast cancer.Introduction First described in 1979, and initially believed to be an oncogene, p53 was ...
Delays and inadequacies in the diagnostic and treatment pathway downstream from screening likely contribute to increased mortality compared with women receiving prompt, effective care. Disparities in follow-up after screening and treatment have been observed for Asian, Black, and Hispanic women.27-36 ...
Breast Cancer Research and Treatment is a comprehensive forum dedicated to all aspects of breast cancer research. The journal's focus spans across various ...
The introduction of the clinical pathway, to which all specialists involved had contributed, led to a significant reorganization of in-hospital operative care processes for the treatment of women with breast cancer. CONCLUSION: The introduction of clinical pathways can lead to a decrease in in-...
The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this pathway represent the main treatment modality. Endocrine therapy has proven successful in the treatment of hormone-responsive breast cancer since its early adoption in the 1940s as an ablative therapy. Unfor...
signaling, interleukin (IL)-12 pathway, and IL-7 pathway. Thus, the IM subtype is highly similar to medullary carcinoma of the breast [16]. It is recommended to use PD1, PDL1, CTLA-4, and other immune checkpoint inhibitors for the treatment of patients with IM subtype breast cancer [14...
regulators (SERDs) are all well-known forms of personalized therapy for HER2 + breast cancer [33,34]. The course of breast cancer is largely influenced by estrogen and ER [35,36]. This is the rationale behind the long-standing practice of inhibiting the estrogen signaling pathway in breast ...
(−) and CKMNF-116(+) (Fig.3i, j). Importantly, Her2 on the infiltrative foci was scored 3+ (positive) and Ki67 was expressed in 50% of the tumor cells, with a high impact on the patient’s correct treatment pathway. Another example of a Tru-cut biopsy from a 39-year-old ...
EIF4A3-mediated circ_0042881 activates the RAS pathway via miR-217/SOS1 axis to facilitate breast cancer progression Chenxi Ju , Mingxia Zhou & Jing He Comment 21 August 2023 | Open Access Cancer stem cell immunoediting by IFNγ The secretion of interferon gamma (IFNG, best known as...
[75]. An earlier example of this mechanism was observed during a thorough examination of the function of MEG3 in breast cancer. It was revealed that MEG3 regulated the TGF-β pathway, where it exerts its function through the formation of an RNA-DNA triplex at the TGFR1 promoter via a ...