Cancer Cell Int, 2013, 13(1):66.Guille A, Chaffanet M, Birnbaum D. Signaling pathway switch in breast cancer. Cancer Cell Int. 2013;13:66. https://doi.org/10.1186/ 1475-2867-13-66.Guille, A.; Chaffanet, M.; Birnbaum, D. Signaling pathway switch in breast cancer. Cancer Cell ...
Hence, targeting these pathways might be a novel therapeutic approach for breast cancer diagnosis and therapy. This review discusses known signaling mechanisms involved in the stimulation or prevention of BCSCs self-renewal, metastasis, and tumorigenesis. 展开 关键词: Breast cancer Breast cancer stem ...
MAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER+) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. Here we integrate...
Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and ...
Here associations with risk of invasive breast cancer are assessed for single-nucleotide polymorphisms (SNP) tagging 17 genes in the canonical TGF-β ALK5/SMADs 2&3 and ALK1/SMADs 1&5 signaling pathways: LTBP1, LTBP2, LTBP4, TGFB1, TGFB2, TGFB3, TGFBR1(ALK5), ALK1, TGFBR2, ...
As for immune cells, neutrophils adopt an anti-tumor phenotype during the initial phases of cancer metastasis. This phenotype is characterized by an absence of MMP, overexpression of pro-inflammatory and anti-cancer signaling pathways such as JAK-STAT, and an increase in interferon signaling (Irf9...
Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes Dis. 5, 77–106 (2018). Article CAS PubMed PubMed Central Google Scholar Vuong, D., Simpson, P. T., Green, B., Cummings, M. C. & Lakhani, S. ...
we have focused our interest on its interaction with estrogen-signaling pathways.MEL could influence estrogenic actions: a) by down-regulating gonadal synthesis of steroids; b) by interacting with the estrogen receptors (ER), thus behaving as selective ER modulators (SERM); and c) by down-regula...
Based on the complexity of the intertwined signaling pathways of breast Conclusion The development of immune-based therapy for breast cancer therapy and the establishment of novel therapeutic approaches such as cancer vaccines require a close investigation of breast cancer oncogenesis and its multiple ...
It is tempting to speculate that AIB1 indirectly regulates c-MYC activity via AKT and E2F1 signaling pathways, as recently reported in bladder cancer to aid in its translational regulation in specific molecular subtypes of breast cancer [22], [23], [38]. It is now becoming increasing evident...