Pharmacologic inhibition of ALDH ac- tivity resulted in accumulation of ROS to toxic levels, causing DNA damage and cell death within the drug-tolerant subpopulation, suggesting that oxidative stress pathways may be a targetable vulnerability of DTPs. This concept has been expanded by several studies...
FASN is the most targetable among lipogenesis genes. Several FASN inhibitors display anti-tumor activity in preclinical cancer models (Table 1). Most importantly, some inhibitors show selective activity against CSCs rather than bulk tumor cells. Strikingly, Orlistat, a FDA-approved anti-obesity drug ...
Cancer cells can detach from the primary tumour, intravasate into the blood or lymphatic system and migrate to distant sites where they extravasate from the blood or lymph vessels to seed secondary sites. Controlling the spread of cancer and outgrowth at these secondary sites remains the most ch...
Iron is extensively involved in many metabolic pathways of the human body and in cells with many physiological functions. The steady state of iron metabolism requires that the expression of a series of proteins be maintained accurately and continuously [16,17]. Iron ions in the form of Fe2+or ...
Cell cycle checkpoint in cancer: A therapeutically targetable double-edged sword. J. Exp. Clin. Cancer Res. 2016, 35, 153. [CrossRef] [PubMed] 67. Chabner, B.; Roberts, T.G. Timeline: Chemotherapy and the war on cancer. Nat. Rev. Cancer 2005, 5, 65–72. [Cro...
In addition, MSI cases were characterized by accumulation of mutations in PIK3CA, ERBB3, HER2, and epidermal growth factor receptor (EGFR), but MSI cancers generally lacked targetable amplifications. Importantly, B-Raf (V600E) mutation was not identified in MSI GCs but was commonly found in ...
Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases J. Clin. Oncol., 28 (2010), pp. 4616-4620 Google Scholar 30 W. Zhou, D.C. Christiani East meets West: ethnic differences in epidemiology and clinical behaviors of lung cancer...
[22]. Efficacy of immunotherapy for those without targetable oncogene mutation was proven from second-line treatment [23,24,25,26,27] to first-line treatment [28,29]. Through long-term follow-up, immunotherapy had also shown itself the greatest potential of long-term clinical benefit [30,31...
thus making this domain particularly targetable by small molecules that interfere with this interaction [141]. Several potent inhibitors are being developed for bromodomains present in the ISWI complexes. NVS-CECR2–1, the first selective inhibitor targeting the CECR2 bromodomain, inhibits chromatin bin...
Brain metastases in lung cancers with emerging targetable fusion drivers. Int. J. Mol. Sci. 21, 1416 (2020). Article CAS PubMed Central Google Scholar Grothey, A. et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, ...