Candelaria Gomez-ManzanoBrain Tumor CenterUniversity of Texas MD Anderson Cancer CenterJuan Fueyo-MargaretoBrain Tumor CenterUniversity of Texas MD Anderson Cancer CenterAutophagyRB-E2F1[J] . Hong Jiang,Vanesa Martin,Marta Alonso,Candelaria Gomez-Manzano,Juan Fueyo-Margareto.Autophagy . 2010 (8)...
that FGF9‐induced Rb phosphorylation led to the dissociation of Rb‐E2F1 complexes and thereby enhanced the transactivations of E2F1 target genes, Cyclin D1, Cyclin E1 and Cyclin A1. Silencing of FGF receptor 2 (FGFR2) us...
p16一Rb:-HDACl一E2F1在胆道癌细胞系中的表达 目的研究p16一RbHDACl一E2F1中各种蛋白及其mRNA在肝外胆管癌和胆囊 癌细胞系中的表达情况。 方法用免疫组织化学和RT—PCR方法检测肝外胆管癌细胞系(QBC。、KMBC、 OZcell lines)和胆囊癌细胞系(Mz—ChA一1cellline)中p16一Rb—HDACl一E2F1 ...
胃肠道间质瘤中p16,MDE2,E2F1,RB表达 薄林会,刘文天,章明放 - 中华医学会全国消化病学术会议 - 0 - 被引量: 0 E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastom...
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3,暴露于高氧中的新生鼠,其肺成纤维细胞的P16基因mRNA及蛋白的表达水平降低,使得Rb蛋白磷酸化和非磷酸化水平发生改变,导致E2F1mRNA及蛋白表达水平升高,最终引起LFs的过度增殖. 4,5-aza-CdR能在细胞水平上逆转P16基因甲基化状态,增强P16基因表达,引发了P16-Rb-E2F1蛋白信号转导通路的改变,对过度增殖的肺成纤维细胞...
developed organoid system that represents the phenotype and transcriptome of GC B cells, here we show that EZH2 mostly explains the GC proliferative phenotype and that this occurs in aCDKN1A-dependent manner, within a positive pro-proliferative regulatory feedback loop also involving E2F1 and Rb. ...
MCPIP1 regulatedNFICexons 9 and 10 skipping to promote the production of CTF5 which downregulated cyclin D1-Rb-E2F1 axis to induce cell cycle arrest at G0/G1 stage, ultimately leading to inhibition of TNBC cell proliferation. Full size image ...
In the present study, we monitored E2F1-Rb interactions during human herpesvirus 6A (HHV-6A) and HHV-6B infections of SupT1 T cells. The results have shown the following dramatic alterations in E2F1-Rb pathways compared to the pathways of parallel mock-infected control cultures. (i) The E2F1...