Mechanistically, HR488B obviously decreased the phosphorylation level of the retinoblastoma protein (Rb), and subsequently prevented the release of E2F1 from the E2F1/Rb/HDAC1 complex, which ultimately suppressed the growth of CRC cells. Overall, our study suggests that HR488B, a novel and ...
胃肠道间质瘤中p16,MDE2,E2F1,RB表达 薄林会,刘文天,章明放 - 中华医学会全国消化病学术会议 - 0 - 被引量: 0 E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblast...
In the present study, we monitored E2F1-Rb interactions during human herpesvirus 6A (HHV-6A) and HHV-6B infections of SupT1 T cells. The results have shown the following dramatic alterations in E2F1-Rb pathways compared to the pathways of parallel mock-infected control cultures. (i) The E2F1...
Interaction among Rb/p16, Rb/E2F1 and HDAC1 Proteins in Gallbladder Carcinoma Lining XUSurgery华中科技大学学报:医学英德文版Xin Wang,Kai Huang,Lining Xu.Interaction among Rb/p16, Rb/E2F1 and HDAC1 proteins in gallbladder carcinoma[J... X Wang,K Huang,XU Lining - 《华中科技大学学报:医学英德文...
E2f1, but Not E2f2 or E2f3, Loss Rescues Ectopic Division and Cell Death in the Rb KO RetinaDanian, Chen
p16一Rb:-HDACl一E2F1在胆道癌细胞系中的表达 目的研究p16一RbHDACl一E2F1中各种蛋白及其mRNA在肝外胆管癌和胆囊 癌细胞系中的表达情况。 方法用免疫组织化学和RT—PCR方法检测肝外胆管癌细胞系(QBC。、KMBC、 OZcell lines)和胆囊癌细胞系(Mz—ChA一1cellline)中p16一Rb—HDACl一E2F1 ...
Feng M, Yu Q. miR-449 regulates CDK-Rb-E2F1 through an auto-regulatory feedback circuit. Cell Cycle (2010) 9(2):213-4. doi:10.4161/cc.9.2.10502M. Feng, Q. Yu, MiR-449 regulates CDK-Rb-E2F1 through an auto-regulatory feedback circuit, Cell Cycle 9 (2010) 213-214....
E2F1 is required by the cell-cycle machinery for entry of cells from G1 phase to S phase of cell cycle. Thus, the activity of E2F1 is tightly regulated by the RB protein (Hsieh et al, 1997; Lauricella et al, 2001). Hyper- phosphorylation of RB by the CDK4/6-Cyclin D complex ...
此外,在严重联合免疫缺陷小鼠异种移植模型中,FGF9显著促进了MA‐10肿瘤的生长,这是细胞增殖增加和凋亡减少的结果。结论是,FGF9与FGFR2相互作用,激活ERK1/2、Rb/E2F1和细胞周期通路,在体外诱导MA‐10细胞增殖和体内肿瘤生长。 01丨 引言 请...