senescencemicroRNAPurpose Progressive, irreversible radiation-induced pulmonary fibrosis (RIPF) is a clinically significant intermediate- to a late-occurring side effect of radiotherapy. Known mechanisms of RIPF include oxidative stress-induced activation of TGF-尾 with activation of SMAD signaling, TNF-...
Fibrosis is a common sequela of both cancer treatment by radiotherapy and accidental irradiation and has been described in many tissues, including skin (Brocherion et al. 1986), lung (Bentzen et al. 1989), heart (Lopez Cardoso et al. 1985) and liver (Fajardo and Stewart 1973). Fibrotic ...
Purpose Radiation-induced cardiac toxicity is a potential lethal complication. The aim of this study was to assess whether there is a dose dependent relationship between radiation dose and myocardial fibrosis in patients that received neoadjuvant chemoradiation (nCRT) for esophageal cancer (EC). ...
Radiation-induced fibrosis in the bladder is strain dependent, suggesting that there may be a genetic predisposition to radiation sensitivity of the bladder. These results are essential in determining the right preclinical model for future RC studies and understanding which cancer patients are at risk ...
Three cases of cardiac fibrosis are presented in which radiation is suggested as the cause. In one, death occurred as a result of fibrosis involving the conducting system twenty-three years after radiation; in another, rupture of the apex of the heart occurred fourteen months after radiotherapy....
Background Radiation-induced fibrosis (RIF) is a late complication of radiotherapy that results in progressive functional and cosmetic impairment. Autologous fat has emerged as an option for soft tissue reconstruction. There are also sporadic reports suggesting regression of fibrosis following regional lipo...
Smad, but not MAPK, pathway mediates the expression of type I collagen in radiation in- duced fibrosis[ J]. Bioehem Biophys Res Commun ,2012,418 (3) : 457 - 463.Smad, but not MAPK, pathway mediates the expression of type I collagen in radiation induced fibrosis[J] . Hiroyuki Yano,...
Introduction:Radiation-induced lung fibrosis (RILF) is a common complication of thoracic radiotherapy. Metformin has been suggested to have a radioprotective effect.Objective:This study explored the radioprotective effects of metformin on RILF and its mechanisms.Methods:C57BL/6J mice were randomly ...
Intestinal fibrosis is a marked feature of late radiation enteropathy. This study assessed the time dose fractionation relationships of radiation-induced f... CW Langberg,S Torill,JB Reitan,... - 《Acta Oncologica》 被引量: 369发表: 1996年 Immunolocalization of elastase in human emphysematous lung...
Radiation-induced pulmonary fibrosis: New potential targets ? 2023 Société fran?aise de radiothérapie oncologique (SFRO)Radiation-induced pulmonary fibrosis (RIPF) is one of the major and late complications of ra... E Deutsch,L Meziani - 《Cancer Radiotherapie Journal De La Soci閠fran鏰ise De...