Radiation induced fibrosisRadiation therapyIntroductionAbout 30% of patients request breast reconstruction following surgery for breast cancer, but radiation therapy negatively influences the outcome. Post-reconstruction radiotherapy is associated with more complications, including more severe capsular contracture ...
Fibrosis is a frequent complication of therapeutic radiation delivered to organ sites such as the thorax and pelvic region. We investigated the relationship between function, and biochemical and structural changes in the lung and colon of CBA mice irradiated with 240 kV X-rays. Progressive changes ...
Radiation-induced intestinal fibrosis (RIF) is a chronic toxicity following radiation, and can be very difficult to treat. Pirfenidone is a promising anti-... Sun, Yan-WuZhang, Yi-YiKe, Xin-JieWu, Xue-jingChen, Zhi-FenChi, Pan - 《European Journal of Pharmacology An International Journal》...
Purpose Radiation-induced cardiac toxicity is a potential lethal complication. The aim of this study was to assess whether there is a dose dependent relationship between radiation dose and myocardial fibrosis in patients that received neoadjuvant chemoradiation (nCRT) for esophageal cancer (EC). ...
CONCLUSION: The molecular pathogenesis of RT-induced muscle fibrosis involves the TGF-β1 pathway and its repression of MyoD expression. Our results suggest a correlation between TST/NMES combined therapy and the restoration of TGF-β1/MyoD homeostasis in cervical muscles. TST/NMES is a plausible ...
In one, death occurred as a result of fibrosis involving the conducting system twenty-three years after radiation; in another, rupture of the apex of the heart occurred fourteen months after radiotherapy. It is suggested that the diagnosis of radiation-induced cardiac fibrosis be entertained in ...
As many as 85–95% of patients undergoing radiotherapy experience radiation-induced skin injury (RSI) to some degree [74]. RSI can manifest as either acute or chronic pathology, including desquamation and ulceration early and fibrosis or carcinoma late [74,75]. Ferroptosis is involved in bot...
Thus, transdermal delivery of DFO improves tissue perfusion and mitigates chronic radiation-induced skin fibrosis, highlighting a potential role for DFO in the treatment of oncological patients.doi:10.1097/01.GOX.0000667572.62239.d5Mimi R. Borrelli...
. Early adverse effects of RT are caused by radiation-induced proinflammatory states and include radiation pneumonitis and acute radiation proctitis . Late adverse effects are commonly related to fibrosis ( radiation fibrosis syndrome ), secondary ...
Fig. 1. Radiation-induced fibrosis: pathophysiology. RIF pathogenesis [review in 1] has been highly debated. An old vascular concept based on a theory of gradual ischaemia–hypoxia was developed to account for capillary network destruction after RT. More recent ideas consider reactions of endothelial...