radiation-induced fibrosisradiodermatitisRadiotherapy (RT) has become an indispensable part of oncologic treatment protocols for a range of malignancies. However, a serious adverse effect of RT is radiodermatitis; almost 95% of patients develop moderate to severe skin reactions following radiation ...
Thus, transdermal delivery of DFO improves tissue perfusion and mitigates chronic radiation-induced skin fibrosis, highlighting a potential role for DFO in the treatment of oncological patients.doi:10.1097/01.GOX.0000667572.62239.d5Mimi R. Borrelli...
Fibrosis is a common sequela of both cancer treatment by radiotherapy and accidental irradiation and has been described in many tissues, including skin (Brocherion et al. 1986), lung (Bentzen et al. 1989), heart (Lopez Cardoso et al. 1985) and liver (Fajardo and Stewart 1973). Fibrotic ...
As many as 85–95% of patients undergoing radiotherapy experience radiation-induced skin injury (RSI) to some degree [74]. RSI can manifest as either acute or chronic pathology, including desquamation and ulceration early and fibrosis or carcinoma late [74,75]. Ferroptosis is involved in bot...
Radiation-induced skin injury is a significant adverse reaction to radiotherapy. However, there is a lack of effective prevention and treatment methods for this complication. Ferulic acid (FA) has been identified as an effective anti-radiation agent. Con
et al. An expression analysis of markers of radiation-induced skin fibrosis and angiogenesis in wound healing disorders of the head and neck. Radiation Oncology. 10, 202 (2015). Article Google Scholar Wang, J., Boerma, M., Fu, Q. & Hauer-Jensen, M. Radiation responses in skin and ...
Camphausen K, Mitchell JB, Simone NL (2014) microRNA alterations driving acute and late stages of radiation- induced fibrosis in a murine skin model. ... BA Simone,D Ly,JE Savage,... - 《International Journal of Radiation Oncology Biology Physics》 被引量: 20发表: 2014年 microRNA Alterat...
Cytokines e.g transforming growth factor β (TGF-β) might be involved in the induction of fibrosis. Treatment use emollients. Superoxide dismutase was used as an ointment for radio-fibrosis therapy and obtains a reduction of the fibrosis. In late phases plastic surgery or sometimes cryo-surgery...
Radiation-induced skin injurySingle-cell RNA sequencingCellular signaturesRadiation-induced skin injury (RISI) commonly manifests in cancer patients undergoing radiotherapy (RT). However, a universally accepted standard for treating radiation injury has not yet been established. Our objective was to ...
Chronic radiation dermatitis encompasses later radiation-induced skin changes, includingpostinflammatory hyperpigmentationorhypopigmentation,skin atrophy, telangiectasias, and subcutaneous fibrosis. These findings usually present after the completion of RT and are a distinct entity from nonhealing acute radiation...