Radiation-induced fibrosisRadiation-associated dysphagiaAnimal modelMouseStrap muscleAlthough radiotherapy is commonly used to treat head and neck cancer, it may lead to radiation-associated dysphagia (RAD). There are various causes of RAD, however, the mechanism has not yet been fully identified. ...
Acute:xerostomia,mucositis,stomatitis,dysphagia,odynophagia Chronic:mucosalatrophyand/orfistulas,dental injuries, mandibularosteonecrosis Chest Radiation-induced esophagitis Radiation-induced lung injury Radiation pneumonitis Radiation-induced pulmonary fibrosis ...
also proposed that higher doses to the cricopharyngeal muscle and cervical esophagus were related to radiation-induced dysphagia.44 Considering the fact that many structures are related to radiation-induced dysphagia, Eisbruch et al. developed the concept of dysphagia/aspiration-related structures (...
Radiation-induced pulmonary disease is generally divided into two phases: early pneumonitis and late fibrosis. The acute phase of radiation pneumonitis develops approximately 1 to 3 months after completion of a course of therapy, depending to a large extent on the total dose and the volume of lung...
Eighteen patients presented with grade 3 toxicities: mucositis, dysphagia, induration, and fibrosis and one toxic death from hemorrhage and denutrition [70]. Another phase II clinical trial held in US, concurrent cetuximab combined with radiotherapy, similar results were observed including the 1-year...
Radiation therapy-induced fibrosis typically occurs more than six month after radiotherapy, and is associated with scarring of the lung. Corticosteroids and antibiotics are the main treatments used for mitigating these late side effects (Giridhar 2015). The drug pentoxifylline reduces the production of...
fibrosis of the masticator muscles resulting in trismus, alterations in taste sensations, and dysphagia. Skin and muscle fibrosis leads to trismus in 5-10% of patients. Severe mucositis with head and neck cancers is associated with feeding difficulties compounded by cancer cachexia, impairs healing,...
Fig. 1: Role of radiation in treatment of HNSCC based on stage. Early stage disease is treated with a unimodality approach while later stage disease requires a multimodality approach. Full size image Radiation-induced DNA damage and repair ...
2015). Studies have discussed the use of PBMT as an effective tool to prevent and to treat the adverse effects of RT in cancer patients such aslymphedema, oral disorders (oral mucositis,oral dryness, taste alteration, dysphagia, xerostomia), radiationfibrosis, and RD (Seité et al., 2017;Be...
Radiological imaging is essential for acute patient management in Intensive Care Units (ICUs); however, it introduces the risk of exposure to ionizing radiation. This review synthesizes research on radiation exposure in ICU settings, highlighting its ris