Prostate Cancer Diagnosis, Treatment Could Be Improved By Protein That Suppresses Androgen ReceptorsToni Baker
Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibition of PPIs has attracted significant attentio
J. Polymer therapeutics: biomarkers and new approaches for personalized cancer treatment. J. Pers. Med. 8, 6 (2018). Article Google Scholar Buck, L. B. & Axel, R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65, 175–187 (1991)....
Treatment strategy of solid tumors requires continuous development. Here the authors develop a Macrophage Drug Conjugate (MDC) platform by loading ferritin-drug complexes to macrophages. MDC transfers the ferritin to cancer cells via ‘TRAnsfer of Iron binding protein’ (TRAIN) process and reduces tumo...
Figure 1. Typical architecture of a eukaryotic protein kinase (ePK) and structural considerations in cancer. A) PKA (PDB: 1ATP) is displayed as the prototypical model of an ePK. The catalytic core is defined by N- and C-terminal lobes separated by a linker that creates an active site cl...
A rare variant of a protein present in nearly all human cells may hold the key to improving the effectiveness of breast cancer treatment, according to University of Manchester research funded by Bre…
“The reason we are interested in standalone therapy is we can recognize Clever-1–positive monocytic cells in circulation in cancer patients,” Jalkanen explains. “So we may already have a surrogate end-marker for both disease and efficacy of treatment, levels of which we can determ...
Cancer Therapy INTRODUCTION “Natural forces within us are the true healers of disease.”—Hippocrates (de Coana et al.,2015). Undoubtedly, the immune system is the right cancer healer, especially in the context of currently available therapies such as chemotherapy, radiotherapy, and targeted therap...
can be addressed as an interesting process to be explored in the development of new therapeutic strategies, particularly for cancer treatment. ERα and AR ERα and androgen receptor (AR) are nuclear receptors that, once activated, are translocated into the nucleus, where they function as transcrip...
Fig. 2. The UPR regulates self-renewal and differentiation in cancer Summarizing overview of the reported UPR sensor-mediated regulation of self-renewal/ proliferation and differentiation in CSCs and during tumorigenesis. Examples of currently known mechanisms are shown for breast cancer, colorectal cance...