Protein for use in the treatment of cancerdoi:US20020187469 A1We have discovered and sequenced MSH5 in this in a number of mammals, including humans. This gene, can be used in assays, to express gene product, for drug screens, and therapeutically.Richard KolodnerNena Winand...
Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibition of PPIs has attracted significant attentio
NOR-1 appears to counteract some of the negative effects on cells that DOX can lead to, including in the heart."Our findings show that NOR-1 can protect the heart after this type of cancer treatment, says Høydal. For the time being, this is still in the laboratory stage, and further...
For 3 years, Protein A of Staphylococcus aureus has been used in cancer treatment, initially because of its potential for removing serum blocking factors in the case of patients with malignancies. Extracorporeal adsorption of plasma over immobilized Protein A has produced beneficial effects on experimen...
treatment for breast cancer is determined by the presence or absence of various biomarkers and the histopathological grade among other considerations [104]. Estrogen-mediated activation of the ER has been implicated in both the development of and continued growth in ER+ breast cancer [2,126]. ...
Based on the dual role of the Tspan protein family for tumors, the study of Tspan on cancer proliferation, prevention, treatment, and prognosis can provide new ideas (Fig. 3). Fig. 3: Signaling pathways of the Tspan protein family regulating tumor cell proliferation. The Tspan protein family...
frequently associated with the oncogenic conversion of two specific protein kinases, RET and BRAF. Small-molecule inhibitors of both kinases have already reached the clinical testing stage. Protein kinases other than RET and BRAF are also being evaluated for their potential in thyroid-cancer treatment...
Additionally, the first oral PROTACs (ARV-110 and ARV-471) have shown encouraging results in clinical trials for prostate and breast cancer treatment, which inspires a greater enthusiasm for PROTAC research. Here we focus on the structures and mechanisms of PROTACs and describe several classes of...
which could be fundamental in designing drugs that target this partnership. It shows for the first time that, although both are needed to fold cancer-causing proteins, HSP90 and CDC37 do not necessarily have to bind to each other directly and so cancer cells can get around blocking their int...
a subject at risk of cancer recurrence, a subject having one or more tumors, or a subject that has previously had tumors or other cancerous cells removed from the body, for example, by surgical resection, or has had cancerous cells ablated by a treatment such as radiation therapy, chemothe...