Research into a protein for treatment of cancer brings prestigious awardtext editorEmerging Infectious Diseases
Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibition of PPIs has attracted significant attentio
12]. In many cases, the application of cancer treatment is what drives loss of the ligand binding site or point mutations which prevent binding [13,14,15,16,17,18,19]. These are expected outcomes for oncoproteins
Based on the dual role of the Tspan protein family for tumors, the study of Tspan on cancer proliferation, prevention, treatment, and prognosis can provide new ideas (Fig. 3). Fig. 3: Signaling pathways of the Tspan protein family regulating tumor cell proliferation. The Tspan protein family...
frequently associated with the oncogenic conversion of two specific protein kinases, RET and BRAF. Small-molecule inhibitors of both kinases have already reached the clinical testing stage. Protein kinases other than RET and BRAF are also being evaluated for their potential in thyroid-cancer treatment...
for elimination. Protein degraders have several potential advantages over small-molecule inhibitors that have traditionally been used for cancer treatment, including their event-driven (rather than occupancy-driven) pharmacology, which permits sub-stoichiometric drug concentrations for activity, their capacity...
“For the first time, our research has shown that without RAC1B, breast cancer stem cells can’t form tumours and become more vulnerable to chemotherapy, making the treatment even more effective. Positively RAC1B isn’t needed for healthy cells so targeting RAC1B...
which could be fundamental in designing drugs that target this partnership. It shows for the first time that, although both are needed to fold cancer-causing proteins, HSP90 and CDC37 do not necessarily have to bind to each other directly and so cancer cells can get around blocking their int...
Cancer treatment can be tough on the body, but for the patient to survive the cancer, it's often necessary to go through with the treatment anyway. Some medications are effective against cancer, but one serious possible side effect is that they may triggerheart damageafterwards. ...
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