The corresponding spatial map of local metabolite competition was visualized for cancer and CD68+ cells. Spatial metabolomic differences of lung tissues from distinct cancer patients Lung cancer is heterogeneous not only at a cellular level48 but also at the patient level with implications in the ...
Individual energy requirements were estimated by age, gender, activity level, and disease-related metabolic stress; protein requirements were estimated at 1.0 g protein/kg BW/d. With diet alone, patients were able to meet only 50% of energy and 80% of target protein intake.83 Considerable ...
Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50. J. Biol. Chem. 273, 13217–13222 (1998). Article CAS PubMed Google Scholar Mustelin, T., Bottini, N. & Stanford, S. M. The contribution of...
Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes in the target oncoprotein which reduce binding affinity. The arsenal of targeted cancer therapies, mo...
For control patients, blood samples were obtained before full colonoscopy, which confirmed that no signs of inflammatory, benign, premalignant or malignant lesions were present in this cohort. For cancer patients, blood samples were obtained before neoadjuvant chemo- or radiotherapy and/or surgery. ...
Protein requirements were less commonly met than energy requirements. Complete case analyses ( = 575) showed that negative predictors for achieving the protein and energy requirements were: nausea (OR = 0.18; 95%CI = 0.06–0.53), cancer (0.57; 0.35–0.93), acute infections (0.63; 0.37–1.01)...
Precancerous or early-stage lesions cannot be efficiently recognized merely by imaging alterations, implying the significance of exploring reliable diagnostic biomarkers [4]. But even for resectable PC, the prognosis of patients is optimistic as a result of rapid postoperation relapse and chemotherapy ...
Although SLNs meet many of the requirements for ocular formulations, as described above, more extensive evaluations are needed to expand the application of SLNs for the ocular delivery of macromolecules such as protein drugs. Niosomes, self-assembling nanovesicles composed of non-ionic surfactants ...
et al. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. J. Biol. Chem. 286, 10628–10640 (2011). CAS PubMed PubMed Central Google Scholar Hoveyda, H., Zoute, L. &...
Activity-based protein profiling (ABPP) facilitates the discovery of deregulated enzymes in cancer. Competitive ABPP yields selective inhibitors for functional characterization of cancer enzymes. ABPP can be integrated with metabolomics to map deregulated enzymatic pathways in cancer. ...