The tumour-suppressor protein BRCA2 is discovered to have a previously undescribed role in maintaining genomic integrity and the sensitivity of PARP1 inhibitors. Sudipta Lahiri , George Hamilton & Eli Rothenberg News & Views | 19 March 2025 Mutations that accrue through life set the stage for ...
overload26,29. As expected, FAC treatment resulted in significant upregulated ODC1 mRNA and protein, as well as enhanced polyamine abundance (Fig.4g–i). Together, these evidences demonstrate that iron overload during ferroptosis process is responsible for RSL3-induced ODC1 activation. Iron overl...
Of the 68 sporadic MLH1 protein-deficient colon cancers, 65 (96%) were found to be deficient due to epigenetic methylation of the CpG island of the MLH1 gene. Deficient protein expression of MLH1 may also have been caused, in the remaining 3 sporadic MLH1 protein-deficient cancers (which ...
Cancer survivors experience the decline in protein synthesis due to physical inactivity (deconditioning) coupled with a possible reduction in the supply of amino acids in protein production, while protein degradation appears to be due to an increased expression of components in the ubiquitin–proteasome...
Cytotoxic T-lymphocyte-associated protein-4 CSC Cancer stem cell DC: Dendritic cell EMT: Epithelial-mesenchymal transition FACS: Fluorescence-activated cell sorting FL: Follicular lymphoma GoT: Genotyping of Transcriptomes HLA: Human leukocyte antigen HSC: Hematopoietic stem cell HTAN Human Tum...
This association results in constitutive normoxic degradation of the HIF-1α protein. Hypoxia, mutation of VHL, or accumulation of reactive oxygen species (ROS) or the TCA cycle intermediates succinate and fumarate impair HIF-1α degradation, allowing it to enter the nucleus and engage in ...
OST-HER2 is an immunotherapy leveraging the immune-stimulatory effects of bacteria to initiate a strong immune response targeting the HER2 protein. In Osteosarcoma, OST-HER2 has completed Phase I & Phase III trials in canines and rece...
Cells were plated in a six-well plate at a density of 0.3 × 106 cells per well and were allowed to attach overnight. After 24 h of treatment with PEITC, cells were harvested and lysed as described under western blotting analysis to collect and estimate the protein. The protein was transf...
Due to the small sample size in many subgroups, the predictive value of ALG3 based on different TP53 status and the tumor types needs to be investigated in a larger sample size in the future studies. It is interesting that breast cancer cell lines with TP53 mutation tended to overexpress ALG...
protein, cutoff criteria are FC ≥ 1.2 or FC ≤ 1.2.e,fScatterplot of log2FoldChange at mRNA and protein levels uponPum1(e) orPum2(f) knockout.g,hExpression changes inPum1−/−cells correlate well with that inPum2−/−cells at both mRNA (g) and protein (h) levels...