Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibition of PPIs has attracted significant attentio
In a phase I clinical trial conducted in HER2-expressing cancer patients, the CHP-HER2 complex vaccine, administered SC, proved to be safe and to induce HER2-specific CD8+ and/or CD4+ T-cell immune responses16; in a second clinical trial with this vaccine, it was further shown to induc...
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et al. Measuring residual estrogen receptor availability during fulvestrant therapy in patients with metastatic breast cancer. Cancer Discov. 5, 72–81 (2015). Article PubMed Google Scholar Zhang, X. et al. Dynamics-based discovery of novel, potent benzoic acid derivatives as orally bioavailable ...
Mass Spectrometry Your partner in cancer biomarker research validation and verification. Software & LIMS Easy-to-use software and data systems to support your oncology research needs.Webinars Biomarker Discovery Translating Proteomics into Clinical Diagnostics...
PROT-AGE recommendations for protein levels in geriatric patients with specific acute or chronic diseases Protein Needs and Recommendations in Older Populations With Disease or Injury Many healthy older adults fail to eat enough dietary protein, but the situation is worsened when they are sick or disa...
For control patients, blood samples were obtained before full colonoscopy, which confirmed that no signs of inflammatory, benign, premalignant or malignant lesions were present in this cohort. For cancer patients, blood samples were obtained before neoadjuvant chemo- or radiotherapy and/or surgery. ...
Tspans were also found to reduce infiltration of tumor immune cells, enrich immune-related signaling pathways, and express immune checkpoint proteins in cancer patients [72]. Tspan9 expression was significantly negatively correlated with tumor immune-cell infiltration and the immune checkpoint CTLA4, ...
As PI3K/Akt inhibition has been suggested as a treatment for OA39,40, whether the decrease in N-glycosylated proteins in the PI3K/Akt pathway inhibits the activity of the PI3K/Akt pathway and thereby exerts a protective effect against OA needs to be further investigated. Most importantly, ...
Doctors in Shanghai have screened two protein markers to determine pancreatic cancer patients' sensitivity to chemotherapy, which may rewrite current treatment guidelines and improve patients' overall survival rate. The team of researchers from Shanghai Ruijin Hospital said on Monday that the results of...