CHICAGO, March 3 (Xinhua) -- Researchers at Washington University School of Medicine in St. Louis have discovered a way to make radiation therapy for colorectal cancer more effective by inhibiting a protein found in cancer cells in the gut. By studying cells, mice and tumor samples from patien...
2020年11月11日Nature在线发表题为Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer的文章(详见BioArt报道:Nature | 抑制PCSK9增强肿瘤免疫治疗效果)证实肿瘤细胞内PCSK9具有肿瘤免疫调节功能,抑制PCSK9可增强肿瘤免疫治...
Nutritional therapy for cancer cachexia: in cancers where high inflammatory stress is usual, protein rich supplements containing n-3 polyunsaturated fatty acids and high levels of antioxidant vitamins can reverse severe weight lossRF Grimble
Transforming growth factor beta (TGF-β) is a signaling protein that normally controls the growth of healthy cells, but cancer can break the rules thanks to a mutation that allows them to spread and evade detection by the immune system. That makes TGF-β a good potential target to help comb...
Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes in the target oncoprotein which reduce binding
PROTAC targeted protein degraders: the past is prologue Article 18 January 2022 Advancing targeted protein degradation for cancer therapy Article 15 June 2021 Targeted protein degradation: from mechanisms to clinic Article 29 April 2024 References...
Recent insights into the therapeutic strategies targeting the pseudokinase PTK7 in cancer Article Open access 21 May 2024 Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy Article Open access 04 June 2022 References Hunter, T. The genesis...
Togashi, Y., Shitara, K. & Nishikawa, H. Regulatory T cells in cancer immunosuppression — implications for anticancer therapy.Nat. Rev. Clin. Oncol.16, 356–371 (2019). ArticleCASPubMedGoogle Scholar Jaiswal, A. et al. Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphobl...
近日，美国MD安德森癌症中心甘波谊研究组在Protein & Cell杂志上发表了名为Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy的综述，总结了SLC7A11表达及其转运蛋白活性的多种调控机制，并讨论了SLC7A11如何通过抑制铁死亡以及其他铁死亡非依赖性的功能促进肿瘤的发展。最后...
peptide for cancer targeting and therapy”的综述论文,讨论用于通过原位,体外,体内和离体筛选方法分离各种癌症特异性配体的噬菌体展示技术的改进。并且介绍了实体肿瘤靶向肽的突出例子,即通过噬菌体展示筛选确定的靶向肿瘤血管的肽,肿瘤微环境(TME)和癌细胞上的过度表达受体,以及在临床中基于靶向肽治疗剂的当前挑战和未...