Lysine crotonylation has been discovered in histone and non-histone proteins and found to be involved in diverse diseases and biological processes, such as neuropsychiatric disease, carcinogenesis, spermatogenesis, tissue injury, and inflammation. The unique carbon–carbon π-bond structure indicates that ...
The review summarizes the tumor-suppressive role of protein lysine methyltransferases (PKMTs), a group of enzymes that add a methyl group to the lysine residues of proteins. The authors highlight three PKMTs – SETD2, SETD7, and EZH2 – which have been found to suppress tumor growth in ...
Protein lysine acetylation has emerged as a key posttranslational modification in cellular regulation, in particular through the modification of histones and nuclear transcription regulators. We show that lysine acetylation is a prevalent modification in enzymes that catalyze intermediate metabolism. Virtually...
The invention provides a human lysine-rich statherin protein (LRSP) and polynucleotides which identify and encode LRSP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing ...
Protein-Lysine 6-Oxidase 中文别名: CBNumber: CB31384434 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商2 Protein-Lysine 6-Oxidase化学性质 安全信息 Protein-Lysine 6-Oxidase性质、用途与生产工艺 Protein-Lysine 6-Oxidase上下游产品信息 ...
ChemicalBook 致力于为化学行业用户提供lysine-rich protein的性质、化学式、分子式、比重、密度,同时也包括lysine-rich protein的沸点、熔点、MSDS、用途、作用、毒性、价格、生产厂家、用途、上游原料、下游产品等信息。
In addition to histones, PTM-regulatory enzymes, such as AMP-activated protein kinase (AMPK) and lysine deacetylases (KDACs or HDACs), can control activity of their substrates (Chalkiadaki and Guarente, 2012, Hardie et al., 2012), many of which are metabolic enzymes. Importantly, the activi...
Human seven-尾-strand (METTL) methyltransferases - conquering the universe of protein lysine methylation Lysine methylation is an abundant post-translational modification, which has been most intensively studied in the context of histone proteins, where it rep... P脴 Falnes,JM Ma艂Ecki,MC Herrera,...
Cleavage specificity Carboxyl side of arginine and lysine residues Amino side of lysine residues Carboxyl side of arginine and lysine residues Carboxyl side of lysine residues Modified? Yes, TPCK-treated and methylated No Yes (trypsin); No (LysC) N...
To elucidate the mechanisms underlying AML1-ETO Lys43 methylation (methylated K43), we sought to identity a co-factor that physically interacts with AML1-ETO and simultaneously possesses protein lysine methyltransferase (PKMT) activity. We used co-immunoprecipitation to verify the AML1-ETO-EZH1 in...