protein methylationresponsetoleranceThe mechanisms underlying the response and adaptation of plants to excess of trace elements are not fully described. Here, we analyzed the importance of protein lysine methylation for plants to cope with cadmium. We analyzed the effect of cadmium on lysine﹎ethylated...
Protein lysine methylation is a crucial post-translational modification that regulates the functions of both histone and non-histone proteins. Deregulation of the enzymes or ‘writers’ of protein lysine methylation, lysine methyltransferases (KMTs), is implicated in the cause of many diseases, includin...
Extensive literature reviews in the field of protein lysine methylation have reported on its cellular functions, including epigenetic regulation, signaling pathways, and various cellular responses. However, literature reviews on the tumor-suppressive functions of PKMTs are lacking. Eighteen PKMTs have been...
The methylation status of histones at different lysine residues is controlled by the reciprocal actions of specific histone lysine modifiers: histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs) (Fig.1). The different activities of KMTs and KDMs in a given cellular context...
Methylation144,145 is a process of addition of methyl group or groups to a molecule, an amino acid, or a nucleotide. At the level of protein, methylation is an addition of a methyl group or groups to the amino acid arginine or lysine, whereas on the DNA level, addition of a methyl gr...
Lysine methylation occurs on both histone and nonhistone proteins. However, our knowledge on the prevalence and function of nonhistone protein methylation is poor. We describe an approach that combines peptide array, bioinformatics, and mass spectrometry to systematically identify lysine methylation sites...
Finally, we present data indicating that VCP-KMT, calmodulin-lysine methyltransferase and eight uncharacterized proteins together constitute a novel human protein methyltransferase family. The present work provides new insights on protein methylation and its links to human disease. 展开 ...
PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53Gaofeng Cui, Sungman Park, Aimee I Badeaux, Donghwa Kim, Joseph Lee, James R Thompson, Fei Yan, Satoshi Kaneko, Zengqiang Yuan, Maria Victoria Botuyan, Mark T Bedford, Jin Q Cheng & Georges Mer...
In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. Mol Cell Biol. 2005;25(11):4552–64. Article CAS PubMed PubMed Central Google Scholar Qiu Y, Zhao Y, Becker M, John S, Parekh BS, Huang S, et al. HDAC1 acetylation is linked to ...
Protein methylation at the surface and buried deep: thinking outside the histone box. Trends Biochem Sci. 2013;38(5):243–52. Article CAS PubMed PubMed Central Google Scholar Hamamoto R, Saloura V, Nakamura Y. Critical roles of non-histone protein lysine methylation in human tumorigenesis....