The protein methyltransferases (PMTs) constitute a class of enzymes that catalyze the methylation of lysine or arginine residues on histones and other proteins. A number of PMTs have been shown to be genetically altered in cancers through, for example: gene amplification, chromosomal translocations, ...
Protein lysine methylation is a crucial post-translational modification that regulates the functions of both histone and non-histone proteins. Deregulation of the enzymes or ‘writers’ of protein lysine methylation, lysine methyltransferases (KMTs), is
acknowledged for its role in suppressing tumors. Each domain is assigned a distinct color to indicate commonalities or differences among various methyltransferases. The universal presence of the red SET domain in all tumor-suppressive lysine methyltransferases, excluding DOT1L, underscores the pivotal ...
Development of Novel PRMT7 Inhibitors for the Treatment of Prostate Cancer 2025, Journal of Medicinal Chemistry DMSO-Related Effects on Ligand-Binding Properties of Lysine Methyltransferases G9a and SETD8 2024, ChemBioChem View all citing articles on Scopus ...
Protein lysine methyltransferases (PKMTs) play crucial roles in histone and nonhistone modifications, and their dysregulation has been linked to the development and progression of cancer. While the majority of studies have focused on the oncogenic functi
[156]. Based on this homology, MLL1 has been classified into a family of histone/protein lysine methyltransferases (KMT) in mammals, which include MLL2-5 and SET1A and B. In complexation with several proteins, MLL1′s SET catalyzes mono-, di-, and tri-methylation of H3K4 [157]. ...
2019). Based on the substrates involved, protein methyltransferases can be divided into categories such as protein lysine methyltransferases (PKMTs) and protein arginine methyltransferases (PRMTs) (Bhat et al. 2021; Dai et al. 2021; Xu and Richard 2021). PKMTs can cause monomethylation, bi...
(Additional file1: Table S1) such as lysine acetyltransferases (KATs), deacetylases (KDACs), protein lysine methyltransferases (PKMTs), protein arginine methyltransferases (PRMTs) and so on that involved in the regulation of PTMs have been discovered in breast cancer [14,15,16,17,18,19,20,...
(Additional file1: Table S1) such as lysine acetyltransferases (KATs), deacetylases (KDACs), protein lysine methyltransferases (PKMTs), protein arginine methyltransferases (PRMTs) and so on that involved in the regulation of PTMs have been discovered in breast cancer [14,15,16,17,18,19,20,...
Protein arginine methyltransferases (PRMTs) and protein lysine methyltransferases (PKMTs) are the predominant enzymes that catalyze S-adenosylmethionine (SAM)-dependent methylation of protein substrates. Broadly, theses enzymes promote a nucleophilic substitution-displacement reaction: methyl additio...