Xenopus LAP2 beta protein is the single isoform expressed in XTC cells. The protein localizes on heterochromatin clusters both at the nuclear envelope and inside a cell nucleus. The majority of XLAP2 beta fraction neither colocalizes with TPX2 protein during interphase nor can be ...
Its relevance was demonstrated by the observation that Herceptin, a humanized monoclonal antibody that targets the ERBB2 receptor (EGF receptor) and which can suppress some malignant breast tumors, reduces SRC-mediated PTEN phosphorylation so enhancing its half-life (Nagata et al., 2004). Likewise,...
This “stripped-down” structure may be a suitable template onto which new functions could be grafted. Another of our initial targets for this design process was the PHD (plant homeodomain) motif. PHD or leukemia associated protein (LAP) domains are found in more than 600 eukaryotic proteins (...
The vaccines of the invention may be designed to elicit an antibody response, a cell-mediated response, or a combination of the two. Like the CS protein; the 16 kDa protein of the present invention is present at the surface of sporozoites. It is therefore most probably carried into the hep...
structure of the Ams1-FW complex was determined at 2.2 Å resolution by cryo-electron microscopy. The FW domain adopts an immunoglobulin-like β-sandwich structure and recognizes the quaternary structure of the Ams1 tetramer. Notably, the N-terminal di-glycine of Ams1 is specifically ...
Provided are salt-free antibody and other protein formulations that are substantially isosmotic and of low viscosity. Also provided are methods for the treatment of diseases using t
Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nat. Commun. 9, 3712 (2018). Article PubMed PubMed Central ADS CAS Google Scholar Koehl, A. et al. Structure of the µ-opioid receptor–Gi protein complex. Nature 558, 547–552 (2018). Article CAS PubMed ...
LAP(Human Leucine aminopepridase) ELISA Kit人亮氨酰氨基肽酶Multi-class antibodies规格:48T TMIGD1英文名称: 跨膜TMIGD1蛋白抗体0.1ml PGGT1B英文名称: 香叶烯基转移酶1β抗体0.2ml Anti-TEM8/FITC荧光素标记内皮标志物8抗体IgGMulti-class antibodies规格:0.2ml ...
Keywords: PLIN2; expression pattern; bovine adipocytes; protein structure; Protein–Protein interaction; mutation model 1. Introduction Lipid droplets (LD), which are generally called vesicles, have a structure similar to small balloons that are full of neutral lipids and anchored by many different ...
FIG. 8-6. Schematic drawing of Dishevelled protein structure. The N-terminal DIX (Dishevelled Axin) domain mediates the binding to Axin (268) and to the actin cytoskeleton (269). Interaction with Frizzled seems to require the PDZ (PSD, Disc-large, and ZO1) and the DEP (Dishevelled, Egl...