Provided are high concentration, salt-free antibody and other protein formulations that are substantially isosmotic and of low viscosity. Also provided are methods for the treatment
The present invention relates to an antibody binding to the transmembrane protein ‘glycoprotein A repetitions predominant’ (GARP) in the presence of TGF-β and uses thereof.
Its relevance was demonstrated by the observation that Herceptin, a humanized monoclonal antibody that targets the ERBB2 receptor (EGF receptor) and which can suppress some malignant breast tumors, reduces SRC-mediated PTEN phosphorylation so enhancing its half-life (Nagata et al., 2004). Likewise,...
However, protein drugs are delicate and easily denatured by the harsh conditions of preparation for tissue engineering scaffolds, which may evoke undesirable antibody responses. None of the tissue engineering scaffolds reported to date have achieved long-term sustained-release of cell growth factor ...
L O'Reilly and J Jimenez for help with protein and antibody production and Dr. F Battye, C Tarlinton, J Chan, D Kaminaris, V Lapatis and Dr. L O'Reilly for help with flow cytometry and confocal microscopy. We are grateful to Drs. A Harris, H Puthalakath and P Bouillet for ...
The vaccines of the invention may be designed to elicit an antibody response, a cell-mediated response, or a combination of the two. Like the CS protein; the 16 kDa protein of the present invention is present at the surface of sporozoites. It is therefore most probably carried into the hep...
A trained gynecologist collected two 3-mm3 biopsies from the superior portion of the ectocervix using Schubert biopsy forceps (model ER058R, Aseculap, Germany). One biopsy was immediately frozen in liquid nitrogen for immunofluorescence staining, one was placed in RNAlater, and both were stored ...
To identify proteins that interact with the NH2terminus of human eBPAG1, we performed a yeast two-hybrid screen, which uncovered a protein belonging to the LAP/LERP (for LRRand PDZ domain) protein family with 16 NH2-terminal leucine-rich repeats and a COOH-terminal PDZ domain. The gene ...
2. The antibody binding to an epitope of a complex formed by human GARP and TGF-β according to claim 1, said epitope comprising at least one of the residues 137, 138, or 139 of GARP (SEQ ID NO: 1) and at least one residue from the Latency associated peptide (LAP) of TGF-β (...
These data clearly indicated that immunization with C-VP1 can efficiently induce anti-CVB3 antibody production. To evaluate the ability of C-VP1 to induce CVB3-specific spleen T cell immune response, T cell proliferation and IFN-γ- producing T cell frequency in spleen were evaluated. As ...