A set of unrelated and rather diverse phosphatases, the dual-specificity phosphatases (DUSP), are incorporated in the family of protein tyrosine phosphatases. Since the first of the DUSP to be identified was VH1, encoded by vaccinia virus, they are sometimes referred to as VH1-like phosphatases...
(LAP) technique. The oligo-Al representatives utilized in Nd-mediated CCTPs of dienes show highly selective alkylation and transalkylation functions. Kinetics and transfer effectiveness studies utilizing 1 H NMR, 13 C NMR, 1 H-13 C HSQC, and Dosy NMR analyses unveiled that the ensuing poly...
(Fig.2d). Glutamate should also fulfill the role of binding the N-terminal free amine group of ligand proteins, but would change the shape of the pocket. We examined the impact of glutamate substitution of D654 on the binding specificity of CtNbr1 FW domain (Fig.4c). The pocket with D...
(1) Protein to which a specific ligand or hapten has been conjugated, used for raising an antibody. (2) Unlabeled protein added into an assay system at relatively high concentrations which distributes in the same manner as the labeled protein analyte that is present in very low concentrations....
In P. falciparum infection, human cytophilic antibodies against MSP1 and MSP2 have been related to inhibition of the red blood cell invasion11. In P. vivax, an antibody profile similar to the one obtained in our study was found to be related to low parasitemias75,76. Anti-PvRMC-MSP1 ...
The FERM domain containing protein Mosaic Eyes (Moe) interacts with Crumbs proteins, which are important regulators of apical identity and size. In zebrafish, loss-of-function mutations in moe result in defects in brain ventricle formation, retinal pigme
In many cases, proteins may contain multiple zinc fingers, which may act either to alter DNA binding specificity, to allow the crosslinking of multiple protein partners, or both. It has also been shown that, for at least two separate classes of zinc binding domains Michael et al. 1992, ...
To ensure the specificity of the BLAST analysis, vimentin (98% sequence identity between human and rat), an interactor of AMPK-a and -b21,41, was used as the positive control. Despite its sequence identity (98%), we con- firmed a homologous interaction between vimentin and AMPK sub- ...
Provided are high concentration, salt-free antibody and other protein formulations that are substantially isosmotic and of low viscosity. Also provided are methods for the treatment
2. The antibody binding to an epitope of a complex formed by human GARP and TGF-β according to claim 1, said epitope comprising at least one of the residues 137, 138, or 139 of GARP (SEQ ID NO: 1) and at least one residue from the Latency associated peptide (LAP) of TGF-β (...