Cabrera CM, Jimenez P, Concha A, Garrido F, Ruiz-Cabello F. Promyelocytic leukemia (PML) nuclear bodies are disorganized in colorectal tumors with total loss of major histocompatibility complex class I expression and LMP7 downregulation. Tissue Antigens. 2004;63: 446-452....
The promyelocytic leukemia (PML) nuclear body (also referred to as ND10, POD, and Kr body) is involved in oncogenesis and viral infection. This subnuclear domain has been reported to be rich in RNA and a site of nascent RNA synthesis, implicating its direct involvement in the regulation of...
The PML protein and PML nuclear bodies (PML-NB) are implicated in multiple cellular functions relevant to tumor suppression, including DNA damage response. In most cases of acute promyelocytic leukemia, the PML and retinoic acid receptor alpha (RARA) genes are translocated, resulting in expression ...
Promyelocytic leukemia protein (PML) is an essential organizer of PML nuclear bodies (NBs), which carry out a variety of activities, including antiviral functions. Herpesviruses from all subfamilies encode proteins that counteract PML NB-mediated antiviral defenses by multiple mechanisms. However, becaus...
The promyelocytic leukemia (PML) protein is aggregated into nuclear bodies that are associated with diverse nuclear processes. Here, we report that the distance between a locus and its nearest PML body correlates with the transcriptional activity and gene density around the locus. Genes on the activ...
promyelocytic leukemia protein APL acute promyelocytic leukemia PML NB PML nuclear body TNFα tumor necrosis factor α CAD caspase-activated DNase MEFs mouse embryo fibroblasts RARα retinoic acid receptor α IFNs interferons PCD programmed cell death DMEM Dulbecco's modified Eagle's medium PBS phosphat...
Promyelocytic leukemia nuclear bodies (PML-NBs) are multiprotein complexes with PML as the main building component [13]. A diverse set of nuclear pro- teins have been identified as permanent or transient PML-NB-binding partners [14]. PML-NBs are highly dynamic structures with respect to ...
PML nuclear bodies. Cold Spring Harb. Perspect. Biol. 21 April 2010 (doi:10.1101/cshperspect.a000661). Melnick, A. & Licht, J. D. Deconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 93, 3167–3215 (1999). CAS...
The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies. Oncogene 1998; 16: 1945–1953. CAS PubMed Google Scholar Koken MH, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JH et al. Leukemia-associated retinoic ...
Targeting promyelocytic leukemia protein: a means to regulating PML nuclear bodies. Int J Biol Sci. 2009;5(4):366–76. Article CAS PubMed PubMed Central Google Scholar Wang ZG, Delva L, Gaboli M, Rivi R, Giorgio M, Cordon-Cardo C, et al. Role of PML in cell growth and the ...