Promyelocytic leukemia (PML) nuclear bodies are disorganized in colorectal tumors with total loss of major histocompatibility complex class I expression and LMP7 downregulation. Tissue Antigens . 2004;63:446–52.Cabrera CM, Jimeez P, Concha A, et al. Promyelocytic leukemia (PML) nuclear bodies ...
The promyelocytic leukemia (PML) nuclear body (also referred to as ND10, POD, and Kr body) is involved in oncogenesis and viral infection. This subnuclear domain has been reported to be rich in RNA and a site of nascent RNA synthesis, implicating its direct involvement in the regulation of...
The promyelocytic leukemia (PML) protein is aggregated into nuclear bodies that are associated with diverse nuclear processes. Here, we report that the distance between a locus and its nearest PML body correlates with the transcriptional activity and gene density around the locus. Genes on the activ...
acta neuropathol commun (2021) 9:66 https://doi.org/10.1186/s40478-021-01174-x RESEARCH Open Access Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load David Marks1†, Natalie Heinen1†, Lisa Bachmann...
The Human Promyelocytic Leukemia Protein is a Tumor Suppressor for Murine Skin Carcinogenesistransgenic mice, tumor suppressor proteins, nuclear bodies, cytokeratin-10, senescence, keratinocytesExpression of the PMLRARα fusion dominant-negative oncogene in the epidermis of transgenic mice resulted in ...
Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia. Proc. Natl Acad. Sci. USA 94, 3978–3983 (1997). This paper demonstrates arsenic trioxide-induced PML and PML-RARα degradation. Article CAS PubMed PubMed Central Google Scholar ...
Acute promyelocytic leukemia (APL) is designated M3 in the French-American-British (FAB) classification. Because of its unique clinical features and unique response to certain differentiation-inducing agents, and because of our advanced understanding of
Promyelocytic leukemia nuclear bodies (PML NBs) have been proposed to be involved in tumor suppression, viral defense, DNA repair, and/ or transcriptional regulation. To study the dynamics of PML NBs during mitosis, we developed several U2OS cell lines stably coexpressing PML-enhanced cyan fluoresce...
Promyelocytic leukemia protein (PML) is an essential organizer of PML nuclear bodies (NBs), which carry out a variety of activities, including antiviral functions. Herpesviruses from all subfamilies encode proteins that counteract PML NB-mediated antiviral defenses by multiple mechanisms. However, becaus...
promyelocytic leukemia protein APL acute promyelocytic leukemia PML NB PML nuclear body TNFα tumor necrosis factor α CAD caspase-activated DNase MEFs mouse embryo fibroblasts RARα retinoic acid receptor α IFNs interferons PCD programmed cell death DMEM Dulbecco's modified Eagle's medium PBS phosphat...