Here we demonstrate that PML bodies form stable interactions with early endosomes immediately following entry into mitosis. The 2 compartments remain stably associated throughout mitosis and dissociate in the cytoplasm of newly divided daughter cells. We also show that a minor subset of PML bodies ...
Promyelocytic leukemia nuclear bodies are membraneless substructures of the nucleus. • SUMOylation is for PML, determining nuclear body formation as well as degradation. • There are permanent as well as transient interaction partners. • PML-NBs play a role in pathways involved in genome ...
Here we present evidence that caspase-2 is localized to the promyelocytic leukemia protein nuclear bodies (PML-NBs), nuclear macro-molecular complexes that are involved in many scenarios of apoptosis including DNA damage. The localization of caspase-2 requires both the prodomain and protease domain ...
PML protein expression in hematopoietic and acute promyleocytic leukemia cells. Blood. 1993;82:1858–67. CAS PubMed Google Scholar Terris B, Baldin V, Dubois S, Degott C, Flejou J-F, Henin D, et al. PML nuclear bodies are general targets for inflammation and cell proliferation. ...
英文名称:mAb anti-human promyelocytic leukemia protein (PML)[promyelocytic leukemia protein],中文名称:抗人早幼粒细胞白血病蛋白,产品货号:MBS592014,[产物类型:抗体产物基因名称:[PML]反应性:人。其他未经检测的病毒:白血病描述:该
The promyelocytic leukemia gene was first identified through its fusion to the gene encoding the retinoic acid receptor alpha (RARα) in acute promyelocytic leukemia (APL) patients. The promyelocytic leukemia gene product (PML) becomes conjugated in vivo
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1. Promyelocytic leukemia (PML) nuclear bodies are disorganized in colorectal tumors with total loss of major histocompatibility complex class I expression and LMP7 downregulation. [J] . Cabrera CM, Jimenez P, Concha A, Tissue antigens. . 2004,第5期 机译:大肠白血病中的早幼粒细胞白血病(PML)...
Nucleoporins and the promyelocytic leukemia protein (PML) represent structural entities of nuclear pore complexes and PML nuclear bodies, respectively. In addition, these proteins might function in a common biological mechanism, because at least two different nucleoporins, Nup98 and Nup214, as well...
acute promyelocytic leukemiaRARAder(5)t(517all-trans retinoic acidPML nuclear bodiesTypical acute promyelocytic leukemia (APL) is associated with the t(15;17) translocation, expression of a PML/RARA fusion transcript, and responsiveness to all-trans retinoic acid (ATRA). Rare APL cases implicating...