Acute promyelocytic leukemia (APL) is characterised by balanced translocation between the longarms of chromoso)ne 15 and 17 resulting in formation of fusion protein PMLlRARa. Due to thisabnormal fusion protein, myeloid cell differentiation is arrested at the promyelocyte level. Thismolecular defect ...
NB4人急性早幼粒白血病细胞英文名字 Human acute promyelocytic leukemia cells供应商 BNCC产品货号 BNCC341933产品报价 ￥询价/支产品说明书 点击查看购买方式 中国区现货中心已经建立,90%产品中国有现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系。本公司所有产品仅供科研使用,不用于...
V. et al. The PML/RARα oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells. Blood 88, 2826–2832 (1996). CAS PubMed Google Scholar Nervi, C. et al. Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARα...
P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are induced by arsenic trioxide (As(2)O(3)), but are not the main mechanism of As(2)O(3)- resistance in acute promyelocytic leukemia cells. Leukemia 17, 648-650....
Mousemodelsofacutepromyelocyticleukemiahavebeen generatedthroughtransgenic,knock-in,retroviral,andxenograftstrategies. 小鼠模型的急性早幼粒细胞白血病已通过转基因,基因敲除中,逆转录病毒,以及异种战略。 www.syyxw.com 2. Theauthorsrecommendedthat thetreatmentbegiven topatientswithbloodandbone marrowcancer,oracutepro...
Sample of cells classified in the Global Test 2023:2 Case Conclusion The peripheral blood film is suspicious for acute promyelocytic leukemia (APL). Numerous abnormal promyelocytes are present with variable nuclear size and shape; and basophilic cytoplasm with granules that vary in number. Auer rod...
There are several types of AML depending on the kind of gene mutations you have, how developed the leukemia cells are when you're diagnosed, and how different they are from normal cells. For instance, one type is called acute promyelocytic leukemia (APL), which occurs when genes from chromos...
Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells X Cai Y Yu G-Q Chen Leukemia (2003) Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1α Y Huang K-M Du G...
Acute promyelocytic leukemia (APL) cells exhibit disrupted regulation of cell death and differentiation, and therefore the fate of these leukemic cells is unclear. Here, we provide the first evidence that a small percentage of APL cells undergo a novel cell death pathway by releasing extracellular ...
The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 1993; 74: 423–431. CAS PubMed Google Scholar Ruthardt M, Testa U, Nervi C, Ferrucci PF, Grignani F, Puccetti E et al. Opposite effects of ...