Definition Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) characterized by the expansion of leukemic cells blocked at the promyelocytic stage of myelopoiesis. According to the French–American–British (FAB) classification of acute leukemia, APL corresponds to ...
Acute promyelocytic leukemia (APL) is characterised by balanced translocation between the longarms of chromoso)ne 15 and 17 resulting in formation of fusion protein PMLlRARa. Due to thisabnormal fusion protein, myeloid cell differentiation is arrested at the promyelocyte level. Thismolecular defect ...
NB4人急性早幼粒白血病细胞英文名字 Human acute promyelocytic leukemia cells供应商 BNCC产品货号 BNCC341933产品报价 ￥询价/支产品说明书 点击查看购买方式 中国区现货中心已经建立,90%产品中国有现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系。本公司所有产品仅供科研使用,不用于...
V. et al. The PML/RARα oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells. Blood 88, 2826–2832 (1996). CAS PubMed Google Scholar Nervi, C. et al. Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARα...
Mousemodelsofacutepromyelocyticleukemiahavebeen generatedthroughtransgenic,knock-in,retroviral,andxenograftstrategies. 小鼠模型的急性早幼粒细胞白血病已通过转基因,基因敲除中,逆转录病毒,以及异种战略。 www.syyxw.com 2. Theauthorsrecommendedthat thetreatmentbegiven topatientswithbloodandbone marrowcancer,oracutepro...
Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all-trans retinoic acid (ATRA). With considerable advances in thera
Sample of cells classified in the Global Test 2023:2 Case Conclusion The peripheral blood film is suspicious for acute promyelocytic leukemia (APL). Numerous abnormal promyelocytes are present with variable nuclear size and shape; and basophilic cytoplasm with granules that vary in number. Auer rod...
Acute promyelocytic leukemia (APL) falls into the latter category. It is composed of malignant promyelocytes, which often have a distinctive appearance. But the really characteristic finding in APL is the faggot cell, so named because it contains a ton of Auer rods all piled up on each ...
Arsenic Trioxide as an Inducer of Apoptosis and Loss of PML/RARα Protein in Acute Promyelocytic Leukemia Cells HumansTumor Cells, CulturedLeukemia, ... W Shao,F Mirco,FF Ferrara,... - 《Jnci Journal of the National Cancer Institute》 被引量: 2394发表: 1998年 United States Multicenter Study...
The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 1993; 74: 423–431. CAS PubMed Google Scholar Ruthardt M, Testa U, Nervi C, Ferrucci PF, Grignani F, Puccetti E et al. Opposite effects of ...