Acute promyelocytic leukemia (APL) is a particular leukemia subset characterized by a unique genetic lesion, i.e. the PML-RAR fusion, and an exquisite response to differentiating agents. Until the late 1980s, APL was considered the most aggressive and rapidly fatal form of acute leukemia. Over...
In this review, we will focus on the key signaling functions of lysosomes, their potential role in the pathophysiology of malignant disease and consider why lysosomes might represent a good therapeutic target for acute myeloid leukemia (AML). Overview of lysosome function, biogenesis, and interaction...
Acute Myeloid Leukemia (AML) - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
Furthermore, current understanding of the pathophysiology of AML mandates that therapeutic decisions be made, in part, on cytogenetic and molecular prognostic factors at diagnosis. This has led to subgroup analyses of small patient cohorts that limit confidence in the results. Maintenance therapy ...
Acute promyelocytic leukemia following ulcerative colitis. Rinsho Ketsueki. 1995;36(7):707–709. 44. Lopez A, Mounier M, Bouvier AM, et al. Increased risk of acute myeloid leukemias and myelodysplastic syndrome in patients who received thiopurine treatment for inflammatory bowel disease. Clin ...
Progress in understanding the pathophysiology and improving the therapy of acute myeloid leukemia (AML) is now occurring at a rapid pace. The discovery of the activity of cytarabine (ara-C) and of anthracyclines in AML, and combining them in the 1970’s, into what is known as the “3 ...
Acute promyelocytic leukaemia (APL) is a subtype of acute myeloid leukaemia (AML), categorised as AML subtype M3, and is characterised by translocation of the genes between the long (q) legs of chromosomes 15 and 17 [described as t(15;17)(q24;q21)]. There are two different classification...
C/EBP[alpha] and the pathophysiology of acute myeloid leukemia. Curr Opin Hematol. 2006;13(1):7–14. CrossRef Ho PA, Alonzo TA, Gerbing RB, et al. Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children’s Oncology...
We analyzed patients with newly diagnosed AML (excluding acute promyelocytic leukemia) who received induction chemotherapy between 1990 and 2010 at MD Anderson Cancer Center, and identified 15 patients who met our criteria of late relapse (Fig.1). Bone marrow (BM) samples collected from patients wi...
Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with an incidence of over 20 000 cases per year in the United States alone. Large chromosomal translocations as well as mutations in the genes involved in hematopoietic prolifer