Promyelocytic leukemia proteinThe promyelocytic leukemia protein (PML) is found in all mammalian cells that have been investigate…Borden, Katherine L. BCuljkovicKraljacic, Biljana
The multitasking promyelocytic leukemia (PML) protein was originally recognized as a tumor‐suppressive factor, but more recent evidence has implicated PML in tumor cell prosurvival actions and poor patient prognosis in specific cancer settings. Here, we report that inducible PMLIV expression inhibits ...
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The apoptosis-associated speck-like protein containing a caspase-activating recruitment domain (ASC) is an essential component of several inflammasomes, multiprotein complexes that regulate caspase-1 activation and inflammation. We report here an interaction between promyelocytic leukemia protein (PML) and ...
早幼粒细胞白血病蛋白(PML蛋白)是核体(PML Oncogenic Domain,POD)的组成成份,它是细胞生长和转化的抑制蛋白。研究表明PML蛋白具有抗肿瘤特性,它在许多肿瘤的形成中起重要作用。 应用类型 ICC (1:100), IP, WB (1:500-1:1000), EMSA 免疫原 Recombinant mouse PML (promyelocytic leukemia protein) (aa 1-581...
Promyelocytic leukemia protein (PML) is an essential organizer of PML nuclear bodies (NBs), which carry out a variety of activities, including antiviral functions. Herpesviruses from all subfamilies encode proteins that counteract PML NB-mediated antiviral defenses by multiple mechanisms. However, becaus...
The acute pro yelocytic leukemia PML-RAR alpha protein induces hepatic preneo- plastic and neoplastic lesions in transgenic mice. Oncogene 1997; 14: 1547-54.David G, Terris B, Marchio A, Lavau C, Dejean A: The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic ...
The promyelocytic leukemia protein (PML) is a growth/tumor suppressor essential for induction of apoptosis by diverse apoptotic stimuli. The mechanism by which PML regulates cell death remains unclear. In this study we found that ectopic expression of PML potentiates cell death by apoptosis in the ...
The promyelocytic leukemia (PML) nuclear body (also referred to as ND10, POD, and Kr body) is involved in oncogenesis and viral infection. This subnuclear domain has been reported to be rich in RNA and a site of nascent RNA synthesis, implicating its direct involvement in the regulation of...
Herpes simplex virus (HSV) 1 disaggregates the nuclear domain 10 (ND10) nuclear structures and disperses its organizing promyelocytic leukemia protein (PML). An earlier report showed that ectopic overexpression of PML precludes the disaggregation of ND10 but has no effect on viral replication. PML...