PML Nuclear Body Component Sp140 Is a Novel Autoantigen in Primary Biliary Cirrhosis. Alessandro Granito,Wei-Hong Yang,Luigi Muratori,Mark J Lim,Ayako Nakajima,Silvia Ferri,Georgios Pappas,Chiara Quarneti,Francesco B Bianchi,Donald B Bloch,Paolo Muratori. The American journal of Gastroenterology . ...
yet the molecular mechanisms bridging the cross talk remain elusive. Herein, we report that a major constitutive component of the PML body, Sp100A, is ubiquitously located in the cytosol of various cell types and is
PML Nuclear Body Component Sp140 Is a Novel Autoantigen in Primary Biliary Cirrhosis PML nuclear body component Sp140 is a novel autoantigen in primary biliary cirrhosis. Am J Gastroenterol 2010; 105: 125-131Grantio A; Yang WH; Muratori L;.PML nuclear body com- ponent Sp140 is a novel aut...
yet the molecular mechanisms bridging the cross talk remain elusive. Herein, we report that a major constitutive component of the PML body, Sp100A, is ubiquitously located in the cytosol of various cell types and is
body and a Nikon CFI Plan Apo Lambda 60× Oil, NA 1.40 objective. All images were deconvoluted using Huygens software (Scientific Volume Imaging B.V.). The main organizing component of PML NBs is the PML protein that forms scaffolds for binding of the interacting proteins. To date, 271 ...
Cao, T., Duprez, E., Borden, K. L., Freemont, P. S. & Etkin, L. D. Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML.J. Cell Sci.111, 1319–1329 (1998). CASPubMedGoogle Scholar ...
Promyelocytic leukemia protein (PML) nuclear bodies (NBs) are essential in regulating tumor suppression, antiviral response, inflammation, metabolism, aging, and other important life processes. The re-assembly of PML NBs might lead to an ~100% cure of ac
subnuclear structure named the PML nuclear body (PML-NB), of which it is the essential component.3The PML-NB is disrupted in APL and loss ofPMLin an animal model of APL results in increased incidence and decreased onset of the disease, thus implicating PML-suppressive function in APL ...
subnuclear structure named the PML nuclear body (PML-NB), of which it is the essential component.3 The PML-NB is disrupted in APL and loss of PML in an animal model of APL results in increased incidence and decreased onset of the disease, thus implicating PML-suppressive function in APL ...
Promyelocytic leukemia nuclear bodies (PML-NBs) are PML-based nuclear structures that regulate various cellular processes. SUMOylation, the process of covalently conjugating small ubiquitin-like modifiers (SUMOs), is required for both the formation and t