The success of macrophage-based adoptive cell therapy is largely constrained by poor polarization from alternatively activated (M2-like) to classically activated (M1-like) phenotype in the immunosuppressive tumor microenvironment (TME). Here, we show that the engineered macrophage (eMac) with a heat-...
Define proinflammatory. proinflammatory synonyms, proinflammatory pronunciation, proinflammatory translation, English dictionary definition of proinflammatory. Adj. 1. proinflammatory - tending to cause inflammation pro-inflammatory unhealthy - not in or
Anterior pituitary cells express receptors for tumor necrosis factor (TNF) and interleukin 1 (IL-1), which can signal these cells to release corticotropin, growth hormone, and cytokines such as IL-1 and macrophage migration inhibitory factor. This interaction provides an important link between...
The immunosuppressive MSCs alleviated excessive inflammation by inhibiting CD4T cell proliferation and promoting the decidual macrophage switch to M2 in a tumor necrosis factor-stimulated gene-6 (TSG-6)-dependent manner. Cell-to-cell contact with proinflammatory macrophages increased the TSG-6 production...
(1999) Detection of macrophage inflammatory protein (MIP)-1 a and MIP-1ββ during experimental endotoxemia and human sepsis. J. Infect. Dis. 179. Google Scholar Olszyna, D.P., Prins, J.M., Dekkers, P.E.P., De Jonge, E., Speelman, P., van Deventer, S.J.H., et al. (...
Clinical data show that disease adversely affects tissue elasticity or stiffness. While macrophage activity plays a critical role in driving disease pathology, there are limited data available on the effects of tissue stiffness on macrophage activity. In this study, the effects of substrate stiffness ...
Kruppel-like factor 4 regulates macrophage polarization Current paradigms suggest that two macrophage subsets, termed M1 and M2, are involved in inflammation and host defense. While the distinct functions of M1 ... X Liao,N Sharma,F Kapadia,... - 《Journal of Clinical Investigation》 被引量: ...
Macrophage-conditioned medium also upregulated IL-6, IL-8, GRO, and MCP-1 mRNA expression and protein levels and led to the novo secretion of ICAM-1, IL-1, IP-10, MIP-1, MIP-1, VEGF, and TNF. Human differentiated adipocytes treated by macrophage-conditioned medium displayed marked ...
TNF, tumor necrosis factor, tumour necrosis factor - a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis) lymphokine - a cytokine secreted by helper T cells in response to sti...
Studies have shown that the upregulation of GLUT1 expression drives the proinflammatory macrophage phenotype [18]. Nevertheless, whether GLUTs are involved in chronic stress-induced microglial activation and learning and memory impairment remains unclear. Thus, the present study’s focus was to unravel...