TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancerdoi:10.3389/fphar.2024.1392328TRP channelsCOLORECTAL cancerWHITE adipose tissueOBESITYPREVENTION of obesityMACROPHAGESADIPOSE tissue physiologyCHOLESTERYL ester transfer proteinDuring ...
Pro-inflammatory M1 macrophage polarization is associated with microbicidal and antitumor responses. We recently described APOBEC3A-mediated cytosine-to-uracil (C>U) RNA editing during M1 polarization. However, the functional significance of this editing is unknown. Here we find that APOBEC3A-mediated ...
These results reveal a crucial new role of BIG1 in regulating macrophage inflammation responses, and provide evidence for BIG1 as a potential promising therapeutic target in sepsis.doi:10.1038/s41419-020-2590-1Lixin LiuSulin ZhangYirui Wang
Myofiber / pro-inflammatory macrophage interplay controls muscle damage in mdx mice. Treatment of mdx mice with NaHS, an H2S donor, reduced the number of pro-inflammatory macrophages in skeletal muscle, which was associated with a ... M Saclier,SB Larbi,H Ly,... - 《Journal of Cell Scienc...
Pore-forming toxins impair pro-inflammatory macrophage responses We found that toxins from one family of PFTs, cholesterol-dependent cytolysins (CDCs), suppressed LPS or IFNγ-stimulated TNFα production and CD69 and CD86 upregulation in a cell-intrinsic manner independently of cell death. CDCs ...
Objective-Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin ...
Ultra-small superparamagnetic iron oxide (USPIO) nanoparticles, which target P-selectin, endothelial vascular cell adhesion molecule (VCAM-1), and scavenger receptors on macrophage-derived foam cells, have been evaluated as a magnetic resonance imaging (MRI) contrast agent [12], [13]. However, ...
A selective jumonji H3K27 demethylase inhibitor modulates the pro-inflammatory macrophage response 来自 EBSCO 喜欢 0 阅读量: 25 作者: E Israeli 摘要: No abstract available.年份: 2012 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 Europe PMC (全网免费下载) EBSCO 211.144.68.84:9998 (...
(Fig. 2); moreover, both the total hepatic macrophage number and CD205+macrophage number in HBs-Tg mice were higher than those in B6 mice (Supplementary Fig. S2); thus, we speculated that these cells arise from circulating monocytes. Ly6C has been widely used to identify functionally ...
Integrin αvβ6 deficiency reduces renal inflammation and pro-inflammatory macrophage infiltration in injured kidneys To further characterize αvβ6 in renal inflammation, a unilateral renal ischemia-reperfusion injury (uIRI)-induced renal fibrosis murine model was adopted. Integrin αvβ6 was not obvi...