Macrophage Activation drug effectsWe have found that the novel phospholipid diacylglycerol pyrophosphate (DGPP), identified in bacteria, yeast, and plants, but not in mammalian cells, is able to potently activate macrophages for enhanced secretion of arachidonate metabolites, a key event in the immuno...
The success of macrophage-based adoptive cell therapy is largely constrained by poor polarization from alternatively activated (M2-like) to classically activated (M1-like) phenotype in the immunosuppressive tumor microenvironment (TME). Here, we show that the engineered macrophage (eMac) with a heat-...
Here we show that ablation of Fgr impairs proinflammatory macrophage polarization while preventing high-fat diet (HFD)-induced obesity in mice. Systemic ablation of Fgr increases lipolysis and liver fatty acid oxidation, thereby avoiding steatosis. Knockout of Fgr in bone marrow (BM)-derived cells ...
Define proinflammatory. proinflammatory synonyms, proinflammatory pronunciation, proinflammatory translation, English dictionary definition of proinflammatory. Adj. 1. proinflammatory - tending to cause inflammation pro-inflammatory unhealthy - not in or
The association of macrophage activity and tissue damage in inflammatory glomerular diseases has recently been established. In nephrotoxic nephritis, ablation of macrophages improved the renal outcome,38 and polarization of CD11b+ splenocytes into the TH1-associated proinflammatory M1 macrophages was capa...
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012;488(7411):404-8. E Israeli - 《Israel Medical Association Journal》 被引量: 0发表: 2012年 Epigenetic regulation of the alternatively activated macrophage phenotype. Alternatively activated (M2...
Macrophage colony stimulating factor (M-CSF) is a microglial activator expressed at increased levels in the brain in Alzheimer’s disease. In monotypic microglial cultures, M-CSF strongly augments amyloid beta (Aβ) induced microglial production of proinflammatory cytokines and nitric oxide. However, ...
After injury in csf1ra/b mutants, we observed a strong reduction in the number of microglial cells (to 17% of wildtype), but an increase in macrophage numbers (by 55% compared to wildtype) in the injury site (Fig. 3a, c). Interestingly, neutrophil numbers were also strongly reduced (...
Collectively, these results demonstrate that alveolar type II cells, in conjunction with alveolar macrophage-produced TNF-alpha, contribute to the initiation of acute pulmonary IR injury via a proinflammatory cascade. The release of key chemokines, such as KC and MIP-2, by activated type II cells...
Generally, the process of macrophage polarization to the M1 direction requires the induction of interferon-gamma (IFN-γ) as a priming signal. IFN-γ is secreted by activated lymphocytes such as CD4+ and CD8+ T cells, gamma delta T cells, natural killer cells, and other immune cells11. IFN...