Role of macrophages in lung inflammationLoems Ziegler-HeitbrockInflammation Research
Accumulating data also point to a role of macrophage TRPV4 in the pathogenesis of the foreign body response, a chronic inflammatory condition, through the formation of foreign body giant cells. Deletion of TRPV4 in macrophages suppresses the allergic and nonallergic itch in a mouse model, ...
The macrophage is a prominent inflammatory cell in wounds, but its role in healing remains incompletely understood. Macrophages have many functions in wounds, including host defence, the promotion and resolution of inflammation, the removal of apoptotic cells, and the support of cell proliferation and...
Macrophages are central to the inflammatory response and its ability to resolve effectively. They are complex cells that adopt a range of subtypes depending on the tissue type and stimulus that they find themselves under. This flexibility allows them to play multiple, sometimes opposing, roles in ...
Macrophages, regarded as the paramount immune cells in the body, are omnipresent from their inception to the culmination of disease progression and exert a significant influence on the pathophysiology of CNS inflammation, thereby precipitating neurodegenerative diseases. Despite the protective function of th...
Acupuncture is used in the treatment of a variety of inflammatory conditions and diseases. However, the mechanisms of its anti-inflammatory action are complex and have not been systematically investigated. Macrophages are key components of the innate imm
Extensive experimental and clinical data support a central role for macrophages in the development and progression of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Liver-resident Kupffer cells initiate inflammation and help recruit blood-derived monocytes; both differentia...
In this review, considering the protein structure and the acting mechanisms of MIF, we mainly discuss the important role of MIF in pathogenesis of inflammatory diseases and graft rejection. 展开 关键词: Macrophage migratory inhibitory factor Macrophages Transplantation Inflammation Graft rejection ...
In summary, we identified the Mas axis as an important factor in macrophage function during inflammation of the central nervous and vascular system in vivo. Modulating the Mas axis may constitute an interesting therapeutic target in multiple sclerosis and/or atherosclerosis. 展开 ...
Its primary function is to stimulate the retention of macrophages at the site of inflammation and thus facilitate the eradication of the pathogen5. This role of MIF might be considered detrimental in the circumstances of, for example, ulcerative colitis. Namely, MIF is highly expressed in the ...