During inflammation, the two kinds of macrophages are activated alternatively, and maintaining a reasonably steady ratio is critical for maintaining homeostasis in vivo. M1 macrophages can induce inflammation, but M2 macrophages suppress it. The imbalance between the two kinds of ...
Notably, macrophages play a crucial role in the creation, maintenance, and regeneration of new tissues in healthy organisms [17]. During inflammation, the number of resident cells decreases, circulating monocytes differentiate into tissue-resident cells to replenish tissue macrophages, and most ...
TRPV4 regulates lipid-laden macrophage foam cell formation, the hallmark of atheroinflammatory conditions, in response to matrix stiffness and lipopolysaccharide stimulation. Accumulating data also point to a role of macrophage TRPV4 in the pathogenesis of the foreign body response, a chronic ...
Their central role in the inflammatory process is reflected in macrophage dysfunction being implicated in chronic inflammation and poorly healing wounds. In this study, we discuss recent attempts to model mathematically and computationally the macrophage and how it partakes in the complex processes of ...
Macrophage-migration inhibitory factor: role in inflammatory diseases and graft rejection. Javeed A, Zhao Y, Zhao Y. Macrophage-migration inhibitory factor: role in inflammatory diseases and graft rejection. Inflamm Res 2008;57:45-50... A Javeed,Y Zhao,Y Zhao - 《Inflammation Research Official ...
Hence, it is important to further delineate the role of Arg-II in obesity-associated NAFLD and the underlying mechanisms. In this study, we demonstrate that Arg-II deficiency protects against obesity-associated NAFLD in mice through suppression of liver macrophage-mediated pro-inflammatory responses ...
Inflammation is a host response defined by the infiltration of immune cells into the affected tissue and plays a key role in medi- ating the host defense against pathogens, as well as *Correspondence: xuzhifangmsn@hotmail.com; 1457907206@qq.com †Jiaqi Wang and Shanshan Lu contributed equally...
The macrophage is a prominent inflammatory cell in wounds, but its role in healing remains incompletely understood. Macrophages have many functions in wounds, including host defence, the promotion and resolution of inflammation, the removal of apoptotic cells, and the support of cell proliferation and...
While traditional macrophages have long been recognized for their role in inflammation and pathogen clearance, it is now widely accepted that a key aspect of macrophage biology is the maintenance of tissue homeostasis and organ function. In fact, most tissues have their own resident macrophages ...
Macrophages have diverse phenotypes and functions due to differences in their origin, location and pathophysiological context. Although their main role in the liver has been described as immunoregulatory and detoxifying, changes in macrophage phenotypes, diversity, dynamics and function have been reported ...