Breast cancer, as the foremost cause of women's death in the world, is highly metastatic and mutable. Resistance to drugs for chemotherapies, endocrine therapies and targeted therapies is an important factor that impacts prognosis of breast cancer. Long non-coding ribonucleic acids (LncRNAs) are ...
but the mechanism of its occurrence has not been elucidated. Non-coding RNAs have numerous functions, and it has been shown that long non-coding RNA (
non-codingRNAspermatozoaSmall non-coding RNAs (sncRNAs) accomplish a huge variety of biological functions. Over the past decade, we have witnessed the substantial progress in the epididymal sncRNA studies. In the Epididymis 7, we had the true privilege of having a whole session to share our ...
Long non-coding RNAs (lncRNAs), although incapable of encoding proteins, play crucial roles in multiple layers of gene expression regulation, epigenetic modifications, and post-transcriptional regulation. Zinc finger antisense 1 (ZFAS1), a lncRNA located in the 20q13 region of the human genome, e...
et al. Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat. Genet. 42, 1113–1117 (2010). Article CAS PubMed PubMed Central Google Scholar Wang, Y. et al. Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human ...
research on the pathogenesis, early diagnosis, and treatment of periodontitis is limited. Circular RNAs (circRNAs), previously considered “splicing noise”, have gained increasing research attention with the development of high-throughput sequencing technologies and bioinformatics. CircRNAs are non-coding ...
MicroRNAs (miRNAs) are 18–25 nucleotides long, single-stranded, non-coding RNA molecules that regulate gene expression. They play a crucial role in maintaining normal cellular functions and homeostasis in organisms. Studies have shown that miR-124-3p is highly expressed in brain tissue and plays...
Research articleOpen access Patient and Public Perceptions of Simulation Training in Neurosurgery: A Two-Stage Cross-Sectional Survey Oliver E. Burton, Joachim Starup-Hansen, Jigishaa Moudgil-Joshi, Simon C. Williams, ... Hani J. Marcus Article 123746 View PDF Article preview select article Impact...
Zamecnik and Stephenson32used specific oligodeoxynucleotide chains that target the 35S RNA of the Rous sarcoma virus to inhibit virus replication, marking a prototype for the application of antisense oligonucleotide (ASO) drugs in disease treatment. As research on transcription and translation advanced, ...
Noncoding RNAs include miRNA, small interfering RNA (siRNA), ribozymes, among others [3]. Both miRNA and siRNA interact with messenger RNA (mRNA), typically marking the mRNA for degradation as will be described in this review. Ribozymes are RNA molecules that bind to mRNA (or other RNAs)...