Long non-coding RNAs (lncRNAs) have emerged as significant players in diverse cellular processes, including cell differentiation. Advancements in computational methodologies have facilitated the prediction of lncRNA functions, enabling insights even in non-model organisms like pathogenic parasites, in roles...
Long non-coding RNAs(lncRNAs)长度大于200 bp,由RNA Pol II从独立启动子转录。与蛋白编码基因相似,它们的基因组位置以转录起始位点的H3K4me3和整个基因编码区的H3K36me3富集为标志。lncRNAs转录本由多个外显子组成,通过经典机制剪接成成熟的转录本,通常包括5'帽子和3'poly(A)尾巴。然而,与蛋白编码转录本相比,...
例如,一个新的lncRNA,它的功能是维持上皮细胞在非分化状态,本来打算命名为ANCR,但是这个名字已经被使用于“快乐木偶 综合症染色体区,Angelman syndrome chromosome region”,所以与作者达成一致,用DANCR来命名这个lncRNA“ differentiation antagonizing non-protein coding RNA”. lncRNA的名字应是描述基因的缩写 每条lnc...
这证实了TSS(转录起始位点)和synteny(共线性)在不同组织中具有较高的保守性,以及表达模式,特别是在那些参与发育的组织中[[polyA lncRNA]]。事实上,最保守的是lincRNAs(Long intergenic non-coding RNAs)亚家族中发育调节的lncrna。 这些lncrna在时空和共时位点表达上具有非常强的保守性,表明其在发育过程中具有选...
Long non-coding RNAs (lncRNAs) are RNA molecules over 200 nucleotides long, lacking protein-coding functions. Initially considered "junk" RNA, they are now recognized as crucial players in cellular processes like chromatin remodeling and gene expression regulation. Despite lacking coding potential, lncR...
然而,lncRNA在大小上存在显著差异,==长度超过10 kb的lncRNA属于超长基因间RNA (very long intergenic RNAs, vlinc)和宏观lncRNA==。这些转录本具有一些区别于其他lncRNA的特征:它们的剪接性差或不剪接,在3 '端弱聚腺苷酸化,并且由特定的基因组位点产生。大多数vlincRNA都位于同一条或相反的链上的PCG(蛋白编码...
LncRNA(Long non-coding RNAs)是一类长度大于200nt但不编码蛋白质,广泛存在于动植物中,具有很强的细胞或组织特异性的RNA分子。IncRNA测序可一次性获取样本中几乎全部的IncRNA信息,对Inc
Messenger RNAs transcribed from olfactory-receptor genes may have non-coding functions that include recruitment of transcriptional enhancers and inhibition of potentially thousands of competing alleles to ensure stable transcription of a single allele. Ariel D. Pourmorady , Elizaveta V. Bashkirova & Stav...
Long noncoding RNAs (lncRNAs) are pervasively transcribed and critical regulators of the epigenome. 1,2 These long, polyadenylated RNAs do not code for proteins, but function directly as RNAs, recruiting chromatin modifiers to mediate transcriptional changes in processes ranging from X-inactivation ...
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 bp and have little or no protein-coding capacity. Once considered as transcriptional noise, significant numbers of lncRNAs have now been identified as modulators of gene expression and functions, and are implicated in a range of develo...