环状RNA(Circular RNA):noncoding RNAs的新明星分子 circRNA是一类以共价封闭环为特征,广泛存在于真核生物中的新型RNA分子。CircRNA来源于基因的外显子或者内含子区域,在哺乳动物细胞中大量存在。现有研究表明大部分的circRNA在不同物种间是保守的。同时,由于其环状结构能抵抗RNase R的降解而比较稳定。circRNA由...
Non-coding RNAs (ncRNAs) are ribonucleic acid (RNA) molecules that are not translated into protein products. Different classes of non-coding RNAs participate in different cellular processes; for example, gene expression regulation (miRNAs, piRNAs, lncRNAs), RNA maturation (snRNAs, snoRNAs) and prot...
Many of the noncoding RNAs have regulatory functions such as microRNA and RNAi and they are conserved across species boundaries. Some of the ncRNAs are much longer (2 kb) than the small RNAs. NRON (noncoding repressor of NFAT ) dramatically affects the function of transcription factor NFAT ...
Messenger RNAs transcribed from olfactory-receptor genes may have non-coding functions that include recruitment of transcriptional enhancers and inhibition of potentially thousands of competing alleles to ensure stable transcription of a single allele. Ariel D. Pourmorady , Elizaveta V. Bashkirova & Stav...
Long non-coding RNAs in oncourology 肿瘤学中的长非编码RNA Differential non-coding RNAs expression profiles of invasive and non-invasive pituitary adenomas 侵袭性和非侵入性垂体腺瘤的差异非编码RNA表达谱 MicroRNAs as prognostic markers and therapeutic targets in gliomas MicroRNA作为胶质瘤的预后标志物和治...
然而,lncRNA在大小上存在显著差异,==长度超过10 kb的lncRNA属于超长基因间RNA (very long intergenic RNAs, vlinc)和宏观lncRNA==。这些转录本具有一些区别于其他lncRNA的特征:它们的剪接性差或不剪接,在3 '端弱聚腺苷酸化,并且由特定的基因组位点产生。大多数vlincRNA都位于同一条或相反的链上的PCG(蛋白编码...
Long non-coding RNAs (lncRNAs) are RNA molecules over 200 nucleotides long, lacking protein-coding functions. Initially considered "junk"RNA, they are now recognized as crucial players in cellular processes like chromatin remodeling and gene expression regulation. Despite lacking coding potential, lncRNA...
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The year 2025 marks the 10th anniversary of Non-Coding RNA (ncRNA, ISSN: 2311-553X), a peer-reviewed open access journal on non-coding RNA research focusing on elucidating the structure, function, and biology of regulatory non-coding RNAs. With an Impact Factor of 3.6 and a CiteScore of...
Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease … Vi...