Osteosarcoma (OS) is the most common primary malignant bone tumor in children and teenagers and is characterized by high malignant potential, rapid disease progression and high disability and mortality rates. R
Long noncoding RNAs (lncRNAs) have emerged as integral regulators of physiology and disease, but specific roles of lncRNAs in bone disease remain largely unknown. Here, we show that lnc-ob1 regulates osteoblast activity and bone formation in mice by upregulating the osteogenic transcription factor ...
Chapters and Articles You might find these chapters and articles relevant to this topic. Chapter Long noncoding RNAs in cancer: From discovery to therapeutic targets Abstract Long noncoding RNAs(lncRNAs) have recently gained considerable attention as key players in biological regulation; however, the ...
After their acceptance as building blocks of the spliceosome, other abundant classes such as small nucleolar (sno)RNAs joined the ranks of ncRNAs. The revolution gained huge momentum in the early 2000s with the discovery of micro (mi)RNAs and their many relatives, underscoring the importance of...
Long noncoding RNAs (lncRNAs) play important roles in diverse cellular processes and carcinogenesis. Homeobox A cluster antisense RNA 2 (HOXA〢S2) is a 1048‐bp lncRNA located between human HOXA3 and HOXA4 genes, whose over゛ctivation was previously found to promote the proliferation and ...
Therefore, identifying novel mechanisms and therapeutic targets that can modulate ischemic heart failure in DM patients will have enormous implications for the current methods of treating patients.Several noncoding RNAs have been implicated in diabetes and associated with heart failure [...
This review summarizes recent findings on the role of M2 tumor-associated macrophages (TAMs) and their exosome-derived non-coding RNAs (ncRNAs) in cancer cell resistance to therapeutics. M2 TAMs promote angiogenesis, suppress immune responses, and facilitate metastasis, thereby creating a tumor-support...
Next-generation sequencing of the human genome revealed the unexpected finding that < 2% of the total genome sequence encodes proteins [1], yet up to 90% of eukaryotic genomes are transcribed, generating noncoding (nc) RNAs that lack an open reading frame and have no protein-coding potential...
Exosomes are a subpopulation of the tumour microenvironment (TME) that transmit various biological molecules to promote intercellular communication. Exosomes are derived from nearly all types of cells and exist in all body fluids. Noncoding RNAs (ncRNAs)
Noncoding RNAs (ncRNAs) have been identified as key regulatory factors in tumors and the immune system. Consequently, ncRNAs show promise as targets to improve the efficacy of immunotherapy in tumors. However, the relationship between ncRNAs and tumor immune escape (TIE) has not yet been ...