环状RNA(Circular RNA):noncoding RNAs的新明星分子 circRNA是一类以共价封闭环为特征,广泛存在于真核生物中的新型RNA分子。CircRNA来源于基因的外显子或者内含子区域,在哺乳动物细胞中大量存在。现有研究表明大部分的circRNA在不同物种间是保守的。同时,由于其环状结构能抵抗RNase R的降解而比较稳定。circRNA由...
Non-coding RNAs (ncRNAs) are ribonucleic acid (RNA) molecules that are not translated into protein products. Different classes of non-coding RNAs participate in different cellular processes; for example, gene expression regulation (miRNAs, piRNAs, lncRNAs), RNA maturation (snRNAs, snoRNAs) and prot...
Messenger RNAs transcribed from olfactory-receptor genes may have non-coding functions that include recruitment of transcriptional enhancers and inhibition of potentially thousands of competing alleles to ensure stable transcription of a single allele. Ariel D. Pourmorady , Elizaveta V. Bashkirova & Stav...
Non-coding RNAs are a class of transcripts that do not encode proteins. They include microRNA (miRNA), long noncoding RNA (lncRNA) and circular RNA (circRNA). They have important biological functions such as regulating transcription and translation, as well as interacting with DNA, RNA, and ...
1)、Noncoding RNAs have very important functions. Are SINE elements genomic junk? SINEs proliferate in the genome through the RNA intermediate. This process, called retroposition, requires a reverse transcription of the RNA and its subsequent insertion into the genome. The insertion can occur in ...
Non-coding RNAs and glioma The uncontrolled proliferation, invasion, and migration of cancer cells are considered to be the hallmark features of tumors. The survival of cancer patients is affected by the migration of the malignant cells and their ability to invade into other organs.62 Specific int...
Roberts TC, Morris KV, Wood MJA. The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease. Philosophical Trans Royal Soc B: Biol Sci. 2014;369(1652):20130507. ArticleGoogle Scholar Mukherjee N, et al. Integrative classification of human coding and noncoding...
have been discovered and classified based on their size or function into many kinds, including miRNAs (microRNAs), siRNAs (small interfering RNAs), piRNAs (piwi-interacting RNAs), rRNAs (ribosomal RNAs), snRNAs (small nuclear RNAs), lncRNAs (long noncoding RNAs), or circRNAs (circular RNAs)....
例如BANCR就是由‘BRAF-activated non-protein coding RNA’短语的首字母排列而成。这样让人们容易理解名字的含义。 lncRNA的名字应仅由拉丁字母和阿拉伯数字组成 每条lncRNA的标识中不应出现标点符号,但可以用字母或者数字来代替标点符号。 连字符仅在特殊场合使用。例如:反义编码蛋白基因可在标识中加连字符(BACE1-AS...
The RNA components of the spliceosome, uridine-rich (U) snRNAs, can regulate tissue-specific and cancer-specific alternative splicing [53]. Notably, recurrent mutations in U1 snRNA, as one of the most abundant noncoding RNAs, have been recently identified in multiple cancer types and play an ...