环状RNA(Circular RNA):noncoding RNAs的新明星分子 circRNA是一类以共价封闭环为特征,广泛存在于真核生物中的新型RNA分子。CircRNA来源于基因的外显子或者内含子区域,在哺乳动物细胞中大量存在。现有研究表明大部分的circRNA在不同物种间是保守的。同时,由于其环状结构能抵抗RNase R的降解而比较稳定。circRNA由...
Non-coding RNAs (ncRNAs) are ribonucleic acid (RNA) molecules that are not translated into protein products. Different classes of non-coding RNAs participate in different cellular processes; for example, gene expression regulation (miRNAs, piRNAs, lncRNAs), RNA maturation (snRNAs, snoRNAs) and prot...
Messenger RNAs transcribed from olfactory-receptor genes may have non-coding functions that include recruitment of transcriptional enhancers and inhibition of potentially thousands of competing alleles to ensure stable transcription of a single allele. Ariel D. Pourmorady , Elizaveta V. Bashkirova & Stav...
Non-coding RNAs in Regenerative Medicine Edited byDr. Leon J. De Windt Maastricht University, Maastricht, The Netherlands,Dr. Mauro Giacca International Centre for Genetic Engineering and Biotechnology, Trieste, Italy 8 August 2023 Long non-coding RNAs in Cancer ...
What potential roles do Non Coding RNAs (nc-RNAs) have as biomarkers or therapeutic targets in cancer? How do Long Noncoding Rnas (lncRNAs) regulate gene expression related to chromatin architecture and protein translation in the skin? What role do Long Noncoding Rnas (lncRNAs) play in the pa...
Protein-encoding genes only constitute less than 2% of total human genomic sequences, and 98% of genetic information was previously referred to as “junk DNA”. Meanwhile, non-coding RNAs (ncRNAs) consist of approximately 60% of the transcriptional outpu
Roberts TC, Morris KV, Wood MJA. The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease. Philosophical Trans Royal Soc B: Biol Sci. 2014;369(1652):20130507. ArticleGoogle Scholar Mukherjee N, et al. Integrative classification of human coding and noncoding...
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 bp and have little or no protein-coding capacity. Once considered as transcriptional noise, significant numbers of lncRNAs have now been identified as modulators of gene expression and functions, and are implicated in a range of develo...
LncRNAs, long non-coding RNAs; EMT, epithelial mesenchymal transition; DKD, diabetic kidney disease; H19, imprinted maternally expressed transcript; PVT1, plasmacytoma variant translocation 1; NEAT1, nuclear enriched abundant transcript 1; NKILA, NF-kappaB interacting lncRNA; HISLA, HIF-1α-...
lncRNA = long non-coding RNA; LIT = low-intensity training; MBOAT2 = membrane bound O-acyltransferase domain containing 2; MICT = moderate-intensity continuous training; miRNA = microRNA; n.a. = not applicable; ncRNAs = non-coding RNAs; NGS = next-gen...