Pro-apoptotic genes BAX and CD40L are predictors of survival in transitional cell carcinoma of the bladder. Br J Cancer 2003; 88: 586-92.Hussain SA, Ganessan R, Hiller L, et al. Proapoptotic genes BAX and CD40L are predictors of survival transitional cell carcinoma of the bladder [J]. ...
gain-of-function ofmiR-277rescues both structurally as well as functionally the Aβ42-mediated neurodegeneration. Furthermore, we identifiedhead involution defective(hid), an evolutionarily conserved proapoptotic gene, as one of the targets
Thus, diabetes-enhanced apoptosis represents an important mechanism through which healing is impaired, and this can be explained, in part, by diabetes-increased expression of proapoptotic genes and caspase activity. 展开 关键词: Diabetes DOI: 10.2337/diabetes.55.02.06.db05-1201 ...
We demonstrated that proapoptotic genes PUMA and Bid are involved in the regulation of autophagic cell death. When wild-type (WT), Baxand PUMAHCT116 cells were exposed to irradiation, we found that, compared with WT, Baxcells showed significantly decreased cell death because of Bax deficiency;...
SIVA is induced in response to p53 and E2F1, two tumor suppressor genes that function in cell cycle regulation and apoptosis. Up-regulation of SIVA in itself is sufficient to induce the apoptotic cascade implicating its importance in injury-induced apoptosis. Indeed, a number of tumor tissues ...
Here, we report that expression of the E6 protein from the cutaneous HPV 77 attenuates the UV-induced transactivation of p53-regulated proapoptotic genes Fas, PUMAß, Apaf-1, PIG3. This inhibition of p53-activation of proapoptotic genes by HPV77 E6 is exerted selectively, as the increased ...
Here we demonstrate that IKAP/hELP1 depleted colon cancer-derived cells show enhanced basal expression of some but not all pro-apoptotic p53-dependent genes such as . Moreover, Elongator deficiency causes increased basal and daunomycin-induced expression of the pro-survival serum- and glucocorticoid...
TIAF1 pro-1211 Recombinant Human TGFB1-Induced Anti-Apoptotic Factor 1 TICAM2 pro-1036 Recombinant Human Toll-Like Receptor Adaptor Molecule 2 TIFA pro-1041 Recombiant Human TRAF-Interacting Protein with Forkhead-Associated Domain TIRAP pro-1181 Recombinant Human Toll-Interleukin 1 Receptor (TIR) Dom...
Mechanistically, miR-25-3p directly targeted the pro-apoptotic genes FASL and PTEN and reduced their protein levels. Moreover, miR-25-3p decreased the levels of EZH2 and H3K27me3, leading to derepression of the cardioprotective gene eNOS as well as the anti-inflammatory gene SOCS3. Inhibition...
The p53 protein can induce apoptosis or cell cycle arrest, but effects on cell fate depend on interactions with other regulators such as POU4F2/Brn-3b (Brn-3b), which co-operates with p53 to increase the expression of pro-apoptotic genes. In contrast, the related POU4F1/Brn-3a (Brn-3a...