Both HL60 and KBM-7 cells are more resistant to radiation- and ara-Cinduced apoptosis than BV173 cells. These results suggest that functional p53 is necessary for the activation of Bax and Fas/APO-1 expression. However, elevated p53 protein is not sufficient to activate Fas/APO-1 gene ...
Osteonecrosis of the femoral head (ONFH) is a multifactorial disease leading to severely limited function. By far, the etiology and pathogenesis of ONFH are not fully understood, and surgery is the only effective way to treat ONFH. This study aims to ide
We then examined the ability of various isoforms of p73 and p51 to activate transcription of a reporter gene. This assay showed that p73 β and p51A activated transcription through a consensus p53 binding sequence, while p73 α and p51B isoforms minimally transactivated the p53 reporter gene. ...
Recent data in cell culture has shown that brain neurons are particularly vulnerable to degeneration by apoptosis. Further the inducers that activate the program (e.g. 尾-amyloid, oxidatative damage, low energy metabolism) correspond to ... CW Cotman,JH Su - 《Brain Pathology》 被引量: 201发...
When we analyzed the nature of STAT proteins capable of binding to IL-2Ralpha, pim-1, and IRF-1 GAS elements after cytokine stimulation, we observed IFN-alpha-induced binding of STAT1, STAT3, and STAT4, but not STAT5 to all of these elements. Yet, IFN-alpha was able to activate ...
(TT8, GL3 and EGL 3) interact to activate anthyocyanin synthesis in plants. However, no studies had been published to study the exact function of these bHLH related genes. The function of the DEGs in this study still required further investigation. The expression level of this complex was ...
Decreased CTNNB1 amounts in Shank3∆11(−/−) can potentially be explained by the loss of SHANK3 ankyrin repeat domains interacting with SHARPIN [114], which in turn would stabilize CTNNB1 [115] and additionally activate the Wnt/CTNNB1 pathway [116]. The CREB transcription factor is...
Significantly, GMR-rpr and GMR-grim, but not GMR-hid, dramatically enhanced the eye phenotype of GMR-fl-dcp-1 flies. These results indicate that Reaper and Grim, but not HID, can activate DCP-1 in vivo. 展开 DOI: 10.1128/MCB.20.8.2907-2914.2000 被引量: 121 ...
The enzyme OAS is activated by dsRNA to produce 5'-phosphorylated, 2-5-linked oligoadenylates (2-5A) that activate RNaseL which, in turn, triggers RNA breakdown, leading to multiple biological functions. Although RNaseL is required for IFN antiviral function, there are many aspects of the ...
et al. Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition. Nature 503(7476), 360–364 (2013). Article ADS CAS PubMed PubMed Central Google Scholar Vigneault, C., McGraw, S. & Sirard, M. A. Spatiotemporal expression of transcriptional ...