Both HL60 and KBM-7 cells are more resistant to radiation- and ara-Cinduced apoptosis than BV173 cells. These results suggest that functional p53 is necessary for the activation of Bax and Fas/APO-1 expression. However, elevated p53 protein is not sufficient to activate Fas/APO-1 gene ...
Our study has identified 10 hub genes. The first gene, PTGS2, also known as cyclooxygenase-2 (COX-2), is a key enzyme in the initiation of prostaglandin synthesis and inflammatory responses. The inflammation and cell apoptosis theory proposed that the main pathological process in ONFH was an ...
We then examined the ability of various isoforms of p73 and p51 to activate transcription of a reporter gene. This assay showed that p73 β and p51A activated transcription through a consensus p53 binding sequence, while p73 α and p51B isoforms minimally transactivated the p53 reporter gene. ...
One of the challenges in GWAS is identifying the causal cell type(s) in the heterogenous tissue contributing to the disease pathogenesis. Single-cell gene expression tools provide unprecedented power in revealing cell type-specific gene expression programs in healthy and diseased tissues37. We queried...
The enzyme OAS is activated by dsRNA to produce 5'-phosphorylated, 2-5-linked oligoadenylates (2-5A) that activate RNaseL which, in turn, triggers RNA breakdown, leading to multiple biological functions. Although RNaseL is required for IFN antiviral function, there are many aspects of the ...
BCL-2 and BAX expression and cell proliferation, after partial hepatectomy with and without ischemia, on cholestatic liver in rats: an experimental study Liver regeneration after partial hepatectomy (PHx) is regulated by several factors that activate or inhibit hepatocyte proliferation. Apoptosis seems ...
Significantly, GMR-rpr and GMR-grim, but not GMR-hid, dramatically enhanced the eye phenotype of GMR-fl-dcp-1 flies. These results indicate that Reaper and Grim, but not HID, can activate DCP-1 in vivo. 展开 DOI: 10.1128/MCB.20.8.2907-2914.2000 被引量: 121 ...
This runs counter to the role AMPK exerts on ULK1 kinase activity during autophagy and conflicts with a recent report showing that phosphorylation of STING on Ser-366 helps activate STING-dependent signaling (40). An alternative interpretation is that the S556A mutation in ULK1 prevents its ...
a protein from the serine/threonine kinases family, is essential for the cell division during mitosis. It is also highlighted as one of the essential biomarkers in cancer prognosis, which its overexpression may activate deleterious phosphorylation pathways and induce cancer83. Moreover,AURKAhas also ...
et al. Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition. Nature 503(7476), 360–364 (2013). Article ADS CAS PubMed PubMed Central Google Scholar Vigneault, C., McGraw, S. & Sirard, M. A. Spatiotemporal expression of transcriptional ...