Furthermore, co-immunoprecipitation studies revealed that α-synuclein interacts with the pro-apoptotic proteins PKCδ and BAD, but not with the anti-apoptotic protein Bcl-2 following MPP+ treatment. We also observed that the interaction between PKCδ and α-synuclein does not involve direct ...
Context: Bullous pemphigoid is mediated by autoantibodies primarily targeting two structural proteins of basement membrane hemidesmosomes, BP180 (BPAG2; c... AVA Maria,JG Girard,MS Howard - 《Our Dermatology Online》 被引量: 21发表: 2011年 加载更多研究...
Apoptosis is mediated by the serial activation of caspase family proteins. These proteases are often activated upon the release of cytochrome c from the mitochondria, which is promoted by the proapoptotic Bcl-2 family protein, Bax. This function of Bax is enhanced by the MOAP-1 (modulator of ...
Given that PCAF and its binding partner transcriptional adaptor protein 3 (ADA3) were recently shown to regulate the intrinsic (mitochondrial) pathway to apoptosis via epigenetic regulation of phosphofurin acidic cluster sorting proteins 1 and 2 (PACS1, PACS2), we analyzed PCAF, ADA3, and PACS...
Wild-type alpha-synuclein interacts with pro- apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell ... S Kaul,V Anantharam,A Kanthasamy,... - 《Brain Research Molecular Brain Research》 被引量: 0发表: 2005年 6-hydroxydopamine-induced ap...
In the intracellular death program, hetero- and homodimerization of different anti- and pro-apoptotic Bcl-2-related proteins are critical in the determinat... SY Hsu,A Kaipia,E Mcgee,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 625发表...
Protein disulfide isomerase (PDI) family proteins are classified as enzymatic chaperones for reconstructing misfolded proteins. Previous studies have shown that several PDI members possess potential proapoptotic functions. However, the detailed molecular mechanisms of PDI-mediated apoptosis are not completely ...
Objective: To study the roles of different truncated hepatitis C virus (HCV) core proteins (CORE) in the pathogenesis of HCV persistent infection and hepatocellular carcinoma (HCC) and to assess intracellular localization in transiently transfected cells. Methods: Seven truncated CORE-GFP (green fluore...
Bcl-2-family proteins are central regulators of cell life and death. At least three major classes of Bcl-2-family proteins have been delineated, including proapoptotic proteins that contain several conserved regions of sequence similarity (termed ‘multidomain’). In mammals, the multidomain protein...
Apoptosis Bcl-2 Proteins Confocal Microscopy Membrane Biophysics Vesicles Sorry, something went wrong. Please try again and make sure cookies are enabledCited by (0)1 Both authors contributed equally to this work. 2 Supported by the Max Planck Society, the German Cancer Research Center, and Bundes...