Objective: The B-cell lymphoma/leukemia-2 (Bcl-2) family of proteins governs mitochondrial membrane permeability where the programmed apoptotic process is controlled by the balance between proapoptotic (Bax) and antiapoptotic (Bcl-2) proteins. We aimed to investigate the [Bcl-2]/[Bax] in ...
Lymphoma B Cells Evade Apoptosis through the TNF Family Members BAFF/BLyS and APRIL prosurvival transcription factor NF-kappaB, down-regulates the antiapoptotic proteins Bcl-2 and Bcl-x(L), and up-regulates the proapoptotic protein Bax. ... B He,A Chadburn,E Jou,... - 《Journal of Immun...
regions of amino-acid sequence similarity among the then growing family of both pro- and antiapoptotic Bcl-2 family proteins, resulting in the coining by Korsmeyer in 1994 of the term Bcl-2 Homology (BH) domain.3 Over time, four BH domains would be delineated; BH1, BH2, BH3, and BH4...
9 In contrast, BH3-only proteins (BOPs) use their BH3 domains as ligands for engaging other members of the Bcl-2 family, either suppressing antiapoptotic proteins such as Bcl-2 and Bcl-XL, or activating MDPs such as Bax and Bak.10 The MDPs of mammals include Bax, Bak, and Bok, ...
We found that activation of the proapoptotic BH3-only proteins Bim and Puma in response to glucotoxicity is dependent on the induction of both ER stress and mitochondrial oxidative stress. Furthermore, consistent with our findings in mouse islets, we observed significantly more proapoptotic BH3-...
Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ov... Northern blot hybridization demonstrated expression of Mcl-1 transcripts of 2.3 and 3.7 kb in the ovary and diverse other rat tissues....
Alternatively, avicin may interact with other proteins and lipids that have been implicated as forming the pathways from the selective release of proteins from mitochondria in the early phases of apoptosis: e.g., BAX and ceramide (Schlesinger et al., 1997; Siskind et al., 2002). From an ...
The respective overexpression and downregulation of proapoptotic proteins like cleaved caspase-8, cleaved PARP-1 and Bax and antiapoptotic proteins like Bcl-2 further validated the apoptotic pathway induced by AAL on AML cells. Finally, LC-MS revealed the presence of several compounds like fatty ...
Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis that stimulates proliferation, migration, and metastasis of melanoma. In literature, all studies concerning influences of matrix metalloproteinases (MMPs) and antiapoptotic proteins on VEGF-induced angiogenesis in melanoma patien...
More recently, glucocorticoid-induced antiapoptotic signaling associated with apoptosis resistance has been identified in cells of epithelial origin, most of malignant solid tumors and some other tissues. Despite these huge amount of data demonstrating differential pro- and anti-apoptotic effects of gluco...