Bcl-2, an antiapoptotic protein, is considered asHitesh JaganiNarayanan KasinathanSreenivasa Reddy MekaVenkata Rao JosyulaArtificial cells, nanomedicine, and biotechnology.Antiapoptotic Bcl-2 protein as a potential target for cancer therapy:A mini review. Jagani H,N Kasinathan,S R Meka,et al. ...
To define the mechanisms linking proliferation and apoptotic threshold, we examined the effect of conditionally deleting, the gene that codes the antiapoptotic protein BCL-xL, in cerebellar granule neuron progenitors (CGNPs), and of co-deletinghomologs, antiapoptotic, or pro-apoptotic. We found that...
BACKGROUNDAltered expression of Bcl-2 family proteins has been associated with tumorigenesis and tumor progression as well as resistance to radiotherapy and chemotherapy. In the current study, Bcl-2 family protein expression was examined in oligodendrogliomas and anaplastic oligodendrogliomas, and an atte...
网络抗凋亡蛋白 网络释义 1. 抗凋亡蛋白 第四节 线粒体在细胞凋亡中的关键作用抗凋亡蛋白(antiapoptotic protein): Bcl抗凋亡蛋白(antiapoptotic protein):如Bcl-2、Bc… wenku.baidu.com|基于2个网页
Another BCL2 family protein, MCL1, is expressed in human oocytes during ovarian development, suggesting a role for MCL1 in oocyte survival. To test this, we first examined the expression of MCL1 in the newborn mouse ovary. MCL1 was localized to both oocytes and somatic cells during primordial...
plasma). Bcl-2 may also have intrinsicantioxidant activity. Other proteins,IAPssuch asXIAP(X-linked) and NIAP (neuronal), can directly inhibitcaspases. Additional examples ofantiapoptoticproteins includeprotease inhibitorssuch ascalpastatin, andprotein chaperonessuch as GRP-78 andheat shock protein(HSP)...
Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells Cancer Res, 60 (2000), pp. 1498-1502 Google Scholar [53] S Shangary, DE Johnson Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family...
摘要: Details a study which investigated the biochemical role of the conserved N-terminal homology domain of Bcl-2 family members in apoptotic mitochondrial changes and cell death. DNA transfection and apoptosis assay; Measurement of mitochondrial biochemical parameters; Results and discussion....
Burm.f. against the protein Bcl-2. Docetaxel, a known inhibitor of Bcl-2 was used as a control in this study. All the studied phytocompounds bound within the same binding pocket as that of Docetaxel and thus can be considered as potential inhibitors of Bcl-2 protein. Among the six ...
The BCL-2 protein family, BH3-mimetics and cancer therapy Escape from apoptosis is a key attribute of tumour cells and facilitates chemo-resistance. The 'BCL-2-regulated' or 'intrinsic' apoptotic pathway integrates stress and survival signalling to govern whether a cancer cell will live or die...