The B-cell lymphoma/leukemia 2 (BCL-2) family represents a group of proteins involved in the regulation of the intrinsic (mitochondrial) apoptotic pathway. Approximately 25 members of the BCL-2 family have been grouped into three categories based on structure and function: (1) anti- apoptotic,...
Results 2: VSV infection drives caspase-dependent pro-inflammatory cell death in primary human keratinocytes VSV感染驱动原代人角质形成细胞中caspase依赖的促炎细胞死亡 non-immune cells(Dead or living?)-Guard Proteins——IL1-α——anti-Viruses IL-1家族细胞因子从活细胞或死细胞中释放,这两种事件可以通过...
BCL-2, a key protein in inhibiting apoptosis, has a 65-residue-long highly flexible loop domain (FLD) located on the opposite side of its ligand-binding groove. In vivo phosphorylation of the FLD enhances the affinity of BCL-2 for pro-apoptotic ligands, and consequently anti-apoptotic activit...
Viral control of programmed cell death relies in part on the expression of viral analogs of the B-cell lymphoma 2 (Bcl2) protein known as viral Bcl2s (vBcl2s). vBcl2s control apoptosis by interacting with host pro- and anti-apoptotic members of the Bcl2 family. Here, we show that the...
The BCL-2 family of proteins is comprised of multidomain antiapoptotic proteins (including BCL-2), multidomain proapoptotic proteins (BAX, BAK), and the proapoptotic BH3-only proteins (including BID, BAD, and BIM) (Danial and Korsmeyer, 2004). In response to selected death signals, individua...
The smaller size, higher granularity cells were CD41aLowCD42aLowphosphatidylserineHigh, had a distinctly apoptotic morphology, were unable to develop proplatelets and showed no signaling response. Screening differentiating megakaryocytes for expression of 24 apoptosis genes identified BCL2L2 as a novel ...
Interacts (via the BH4 domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the anti-apoptotic activity of BCL2. Interacts with G0S2; this interaction also prevents the formation of the anti-apoptotic BAX-BCL2 complex. Subcellular Location: ...
Bcl-2同源拮抗剂抗体 0.1ml/100μg0.2ml/200μg BJ-K3446 英文名称Anti-Bak 中文名称Bcl-2同源拮抗剂抗体 别名Apoptosis Regulator Bak; BAK 1; BAK; BAK like; Bak NT; BAK1; Bcl 2 homologous antagonist/killer; Bcl 2 like 7 protein; Bcl2 homologous antagonist killer; Bcl2 like 7 Protein; BC...
anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of ...
The proapoptotic Bcl-2 homolog Bim was shown to control the apoptosis of both T cells and hepatocytes. This dual role of Bim might be particularly relevant for the development of viral hepatitis, in which both the sensitivity of hepatocytes to apoptosis stimuli and the persistence of cytotoxic ...