参考文献 [1] BCL2: A Promising Cancer Therapeutic Target. Biochimica et Biophysica Acta, Reviews on Cancer 2017, 1868, 309-314.[2] BCL-2 protein family: attractive targets for cancer therapy. Apoptosis 2023, 28, 20-38.
01 / Bcl-2结构与分布 图源:basic apoptosis discoveries to advanced selective BCL-2 family Bcl-2基因位于18q21,编码26kd的Bcl-2α和22kd的Bcl-2β两种蛋白质,定位于线粒体、内质网和连续的核周膜,在胚胎组织中广泛表达。其C端的21个疏水氨基酸组成一个延伸...
Upregulation of Bax and Bcl-2 following prenatal cocaine exposure induces apoptosis in fetal rat brain. Int J Med Sci. 2008;5(6):295-302. [6] Alam M, Alam S, Shamsi A, Adnan M, et al. Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell ...
[1] Kale J, Osterlund EJ, Andrews DW. BCL-2 family proteins: changing partners in the dance towards death.Cell Death Differ. 2018;25(1):65-80. doi:10.1038/cdd.2017.186 [2] Ashkenazi A, Fairbrother WJ, Leverson JD, Souers AJ. From basic apoptosis discoveries to advanced selective BCL-2...
上述十大特征之中,凋亡(Apoptosis)是细胞死亡(Cell Death)重要的形式之一,带出今天的主角:B淋巴细胞瘤-2基因(B-cell lymphoma-2,BCL-2)。 BCL-2是最早被发现的细胞死亡调节基因片段。它与许多肿瘤、精神疾病与自身免疫性疾病有关。 BCL-2蛋白可以...
1. P. E. Cippà, S. S. Gabriel, J. Chen, P. D. Bardwell, A. Bushell, A. Guimezanes, A. K. Kraus, T. Wekerle, R. P. Wüthrich, T. Fehr, Targeting apoptosis to induce stable mixed hematopoietic chimerism and long-term allograft survival without myelosuppressive conditioning in ...
图源:basic apoptosis discoveries to advanced selective BCL-2 family Bcl-2基因位于18q21,编码26kd的Bcl-2α和22kd的Bcl-2β两种蛋白质,定位于线粒体、内质网和连续的核周膜,在胚胎组织中广泛表达。其C端的21个疏水氨基酸组成一个延伸的链状结构。Bcl-2α具有抗凋亡作用,但Bcl-2β的特性尚未完全确定。[3-...
1、Bax 中文：BCL2-Associated X的蛋白质。英文：BCL2-Associated X。释义：属于兔抗人单克隆抗体。2、bcl-2 中文：B淋巴细胞瘤-2基因。英文：B-cell lymphoma-2。释义：细胞凋亡研究中最受重视的癌基因之一。
参考文献 [1] BCL2: A Promising Cancer Therapeutic Target. Biochimica et Biophysica Acta, Reviews on Cancer 2017, 1868, 309-314. [2] BCL-2 protein family: attractive targets for cancer therapy. Apoptosis 2023, 28, 20-38.
产品名称:Apoptosis regulator Bcl-2 ELISA Kit 检测范围:78-5000 pg/mL 保存条件:2-8℃低温保存 保质期:6个月,所有试剂盒均提供批次。 试剂盒成分:酶标板,试剂,标准品等。 操作步骤 1.标准品的稀释:本试剂盒提供原倍标准品一支,用户可按照下列图表在小试管中进行稀释。