Bcl2 is anti-apoptotic while Bim is pro-apoptotic. Characterization of the auditory systems of mice deficient for these molecules revealed that Bcl2⁻/⁻ mice suffered severe hearing loss. This was conductive in nature and did not affect sensory cells of the inner ear, with cochlear hair ...
Cancer cells possess many abnormalities that generate apoptotic signals. Moreover, genetic changes that impede apoptosis (such as p53 loss or BCL-2 overexpression) result in cancer and are often found in cancer, supporting a role for blocking apoptosis during tumorigenesis. Here we show that an ap...
Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocation. Chemotherapy resistance from imbalanced apoptosis regulation may contribute to poor outcome in leukaemias with t(4;11). Anti-apoptotic BCL-2 expression and... BW Robinson,KC Behling,M Gupta,... - ...
We here use this system to analyze the role of the poorly characterized anti-apoptotic B-cell lymphoma protein 2 (Bcl-2) family member A1/Bfl-1 (Bcl-2-related protein A1) for survival and homeostasis of neutrophils and of neutrophil progenitors. Low constitutive mRNA and protein expression of...
Bcl-2 serves as critical inhibitors of apoptosis triggered by a broad range of stimuli, mainly acting on the mitochondria. We found a member of the reticulon (RTN) family.RTN3,which did not belong to the Bcl-2 family and was predominantly localized on the endoplasmic reticulum (ER) ,can in...
T cell development is characterized by the induction of apoptosis in most immature thymocytes and the rescue from apoptosis of a small proportion of cells by the process of positive selection.Up-regulation of the anti-apoptotic molecule Bcl-2 is associated with thymocytes undergoing positive selection...
In adults, bcl-2 is topographically restricted to progenitor cells and long-lived cells in tissues characterized by apoptotic cell death. Bcl-2 is ... SJ Korsmeyer - 《Cancer Surveys》 被引量: 344发表: 1992年 Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJBCL2 protein is topogr...
Here we demonstrate that the anti-apoptotic protein, Bcl-2, is highly expressed in RA compared with osteoarthritis synovial tissues, particularly in the CD68-negative, fibroblast-like synoviocyte population. To determine the importance of endogenous Bcl-2, an adenoviral vector expressing a hammerhead...
CC genotype of anti-apoptotic gene BCL-2 (−938 C/A) is an independent prognostic marker of unfavorable clinical outcome in patients with non-small-cell ... Background B cell lymphoma 2 (BCL-2) gene is a well-known regulator of apoptosis and a key element in cancer development and pro...
The latter effect is caused by Navitoclax directly inducing the apoptotic death of platelets, which are dependent on BCL-XLfor survival. Recently, ABT-199, a selective BCL-2 antagonist, was developed. It has shown promising anti-leukaemia activity in patients whilst sparing platelets, suggesting ...