BCL-2 family proteinsIn the body, millions of cells die and proliferate each day to maintain normal function and cooperation of all tissues, organs, and systems. Thus, programmed cell death, or apoptosis, is critical to sustain growth, development, and body health. The vital role of B-cell...
Deals with a study which revealed the role of mammalian Bcl-2 in the regulation of caspase activation. Effects of loss of caspase-9 apoptosome component on the survival of haematopoietic cells; Mechanism of action of the protein; Results of the study....
Etopside (20 μg/ml)could induce K 562 cell apoptosis.[WT5"HZ]Conclusion In the course of this process,expression of bcl-2 mRNA and bcl-2 protein all reduced.These results suggested that the reduction of bcl-2 gene and its product played an important role in K 562 cell apoptosis. ...
We believe that the studies summarized here also provide a proof of principle of yeast as an important tool to elucidate some of the complex mechanisms of apoptotic cell death in higher eukaryotes. 展开 关键词: Apoptosis Bcl-2 family proteins Bax Bcl-2 yeast apoptosis modulation MOMP ...
Expression of Bcl-X(L), an antiapoptotic member of the Bcl-2 family, in esophageal squamous cell carcinoma Bcl-X, a Bcl-2-related protein, is a potent antagonist of apoptosis in its long splice variant (Bcl-X(L)). The present study was performed to determine its... M Torzewski - 《...
Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection. Andrea,Cuconati,Eileen,... - 《Genes & Development》 被引量: 467发表: 2002年 Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins. Bcl-2 is the prototype of a class of oncogenes which...
Aberrations in cell death signaling not only promote tumor survival and enhanced metastatic potential, but also create resistance to anti-tumor strategies. Chemotherapeutic agents target melanoma tumor cells by inducing a form of cell death called apoptosis, which is governed by the BCL-2 family of ...
Examines the role of Bcl-2 proteins in the decision step of apoptosis using an ovarian paradigm. Construction of an ovary-specific protein-protein interact... SY Hsu,Hsueh,JW Aaron - 《Physiological Reviews》 被引量: 373发表: 2000年 The role of metallothionein in oncogenesis and cancer prognos...
Role of Caspases, Bax and Bcl-2 in Chrysin-Induced Apoptosis in the A549 Human Lung Adenocarcinoma Epithelial Cells[J] . Saeed Samarghandian,Mohsen Azimi Nezhad,Gholamreza Mohammadi.Anti-Cancer Agents in Medicinal Chemistry . 2014 (6)Samarghandian S, Nezhad MA, Mohammadi G. Role of caspases...
Bcl-2: Discovery of the First Cell Death Regulator and Its Role in Tumourigenesis The first insights into the role of apoptosis in tumour development came from cytogenetic analysis of human 1The Walter and Eliza Hall Institute of Medical Research, Molecular Genetics of Cancer Division, Melbourne, ...