The role of bax and bcl-2 in gemcitabine-mediated cytotoxicity in uveal melanoma cells. Tumour Biol. 2014;35:1169–75.The role of Bax and Bcl-2 in gemcitabine-mediated cytotoxicity in uveal melanoma cells[J] . Jing Wang,Renbing Jia,Yidan Zhang,Xiaofang Xu,Xin Song,Yixiong Zhou,He Zhang,...
Role of caspases, Bax and Bcl-2 in chrysin-induced apoptosis in the A549 human lung adenocarcinoma epithelial cells. Anticancer Agents Med Chem. 2014; 14:901-9.Samarghandian, S.; Nezhad, M.A.; Mohammadi, G. Role of caspases, Bax and Bcl-2 in chrysin-induced apoptosis in the A549 ...
Bax as well as NF-κB were detected by using immunohistochemistry staining.Results: Regarding to indexes related to apoptosis,the positive expression for Bcl-2,Bax and NF-κBP50 in the experiment group were 39.1%,56.5%,and 47.8% respectively,while in the control group were 78.3%,17.4% and ...
In the present study, we aimed to investigate the functional role of Bax/Bak in lipoapoptosis using mouse embryonic fibroblasts (MEFs) cell culture model. Results showed that palmitate induced caspase-dependent apoptosis in wild-type Bax/Bak MEF cells, whereas a caspase-independent cell death was...
Both UM cell lines showed an increase in Bax protein levels and activation of cleaved Caspase 3. Additionally, SP6.5 cells showed a gradual increase in Bcl-2 expression over time, whereas VUP cells showed almost none. After interfering in the expression of Bcl-2, the sensitivity to GEM was ...
Our results suggest that melatonin in these doses may provide modulation of bax and bcl-2 expression as well as bax/bcl-2 ratio to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis. 展开 关键词: Melatonin Gamma radiation Apoptosis Rat lymphocytes ...
We studied the role of bax mutations on bax expression and apoptosis in 59 primary colorectal cancers of which 41 were microsatellite unstable. Tumors were screened for bax(G)8 mutations and evaluated immunohistochemically for bax, bcl-2, and p53 protein expression and apoptotic (M30 cytoDEATH) ...
Apoptosis regulation in the testis: Involvement of Bcl-2 family members Bcl-2Bcl-xs/lBaxapoptosisspermatogoniamousehumanUsing immunohistochemical techniques and Western blot analysis, the possible role of Bcl-2 family members Bax,... TL Beumer,HL Roepers-Gajadien,IS Gademan,... - 《Molecular Rep...
AIM:To investigate the role of hepatocyte apoptosis-related factors Fas,FasL,Bcl-2,Bax and caspase-8 in the pathogenesis of nonalcoholic fatty liver disease(NAFLD) in rats.METHODS:A rat model of experimental NAFLD was created by feeding a fat rich diet(NAFLD group).Control animals were fed ...
Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family ...