Role of Bcl- 2, Bax, and Bak in spontaneous apoptosis and proliferation in neuroendocrine lung tumors: immu- nohistochemical study. Bull Exp Biol Med 2000; 130:697-700.Pal'tsev MA, Demura SA, Kogan EA, Jaques G, Zende B. Role of Bcl-2, Bax, and Bak in spontaneous apoptosis and ...
Role of Caspases, Bax and Bcl-2 in Chrysin-Induced Apoptosis in the A549 Human Lung Adenocarcinoma Epithelial Cells[J] . Saeed Samarghandian,Mohsen Azimi Nezhad,Gholamreza Mohammadi.Anti-Cancer Agents in Medicinal Chemistry . 2014 (6)Samarghandian S, Nezhad MA, Mohammadi G. Role of caspases...
Our results suggest that melatonin in these doses may provide modulation of bax and bcl-2 expression as well as bax/bcl-2 ratio to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis. 展开 关键词: Melatonin Gamma radiation Apoptosis Rat lymphocytes ...
In the present study, we aimed to investigate the functional role of Bax/Bak in lipoapoptosis using mouse embryonic fibroblasts (MEFs) cell culture model. Results showed that palmitate induced caspase-dependent apoptosis in wild-type Bax/Bak MEF cells, whereas a caspase-independent cell death was...
Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family ...
Conclusion:Our study is the first to evaluate the role of the main SNPs from both the extrinsic and intrinsic apoptosis pathways in RPL susceptibility. The association of BAX-248G/A with RPL susceptibility suggests that maternal predisposition for RPL has an essential contribution from genes ...
Bcl-2 family proteins are potent regulators of programmed cell death. Although their intracellular localization to mitochondria and the endoplasmic reticulum has focused research on these organelles, how they function remains unknown. Two members of the
The BCL-2 family is comprised of anti-apoptotic proteins (e.g., BCL-2, BCL-xL, and MCL-1) and pro-apoptotic proteins (e.g., BAK, BAX, and BIM), and their coordinated regulation and function are essential for optimal responses to chemotherapeutics. Here we will discuss what is ...
We believe that the studies summarized here also provide a proof of principle of yeast as an important tool to elucidate some of the complex mechanisms of apoptotic cell death in higher eukaryotes. 展开 关键词: Apoptosis Bcl-2 family proteins Bax Bcl-2 yeast apoptosis modulation MOMP ...
There is also a significant overlap between events normally associated with apoptosis and APAP-induced cell death. For instance, mitochondrial events generally linked to apoptosis have been observed in APAP-induced hepatic cell death, including the proteolytic processing of the pro-apoptotic Bcl-2 ...