Synonyms BAX ; Bcl-2-associated X protein ; Bcl-2-like protein 4 ; BCL2L4 Historical Background Bax is a proapoptotic protein encoded by Bax gene belonging to B-cell lymphoma 2 (Bcl-2) protein family. Bcl-2 family is classified into two groups: antiapoptotic proteins (e.g., Bcl-2,...
In mammalian cells, pro-survival proteins directly bind pro-apoptotic BAX/BAK-like proteins, which can be readily detected by co-immunoprecipitation (co-IP), though the outcome can be influenced by whether CHAPS or Triton X-100 is used to lyse the cells33. Accordingly, we performed co-IPs ...
using a Bax antibody, non-specific bands were shifted upward; however, the band of immunoprecipitation-purified Bax protein was not changed at all (Fig.S6a). In addition, the
Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancer Int. J. Biochem. Cell Biol., 42 (2010), pp. 210-213 Google Scholar [153] R. Mannhold, S. Fulda, E. Carosati IAP antagonists: promising candidates ...
样本:Apoptosis-associated speck-like protein containing a CARD ELISA Kit 检测方法:详见说明书 应用:ELISA 货号:BK-F98932 是否进口:是 ELISA试剂盒实验原理: ELISA是以免疫学反应为基础,将抗原、牽9体的特异性反应与酶对底物的高效催化作用相结合起来的一种敏感性很高的试验技术。由于抗原、抗体的反应在一种固...
In conclusion, this study clearly shows that LFBE is a regulator of the transplantation tumor of human HT-29 cells in BALB/c nude mice and inhibits cell proliferation and apoptosis induction. Its mechanism may help to increase the gene expression levels of Bax and caspase-3 and decrease those...
The human T-cell leukemia virus-encoded oncoprotein Tax is a potent deregulator of cellular gene expression. Here we report that Tax represses transcription of the human bax gene, a gene whose protein product accelerates apoptosis. This repression is mediated through a 27-bp sequence in the bax...
Recent advance in the study of caspase-like proteases and Bax inhibitor-1 in plants: their possible roles as regulator of programmed cell death [Review] Molecular Plant Pathology . 2004Watanabe N,Lam E.Recent advance in the study of caspase-like proteases and Bax inhibitor-1 in plants: their...
The Bax protein is known to be a key mitochondrial regulator of apoptosis and has been shown to be a transcriptional target of c-Myc (Mitchell et al, 2000). In this latter capacity, Bax may be responsible, in part, for apoptosis resulting from deregulated c-myc expression and its loss ...
Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant. Proc Natl Acad Sci USA 1998; 95: 12424–12431. 15. Kodama T, Takehara T, Hikita H, Shimizu S, Li W, Miyagi T et al. Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice. ...