In bax[sup -/-] bak[sup -/-] cells, introduction of Bak mutants selectively targeted to either mitochondria or the ER can induce apoptosis. However, ER-targeted, but not mitochondria-targeted, Bak leads to progressive depletion of ER Ca[sup 2+] and induces caspase 12 cleavage. In ...
BAX and BAK dynamics control mitochondrial DNA release during apoptosis. Cell Death Differ 29, 1296–1298 (2022). https://doi.org/10.1038/s41418-022-00985-2 Download citation Received21 February 2022 Revised14 March 2022 Accepted14 March 2022 Published26 March 2022 Issue DateJune 2022 DOIhttps:...
Intrinsic apoptosis relies on the ability of the BCL-2 family to induce the formation of pores on the outer mitochondrial membrane. Previous studies have shown that both BAX and BAK are essential during murine embryogenesis, and reports in human cancer cell lines identified non-canonical roles for...
Large BAX/BAK pores that form during apoptosis enable mitochondrial nucleoids to access the cytosol, potentially leading to inflammatory signaling via CGAS. Under physiological conditions, however, BAX/BAK-dependent caspase activation rapidly dismantles dying cells to prevent inflammatory responses. BAX an...
C.E. DempseyD.L. RobertsC. DiveWiley‐VCH Verlag GmbHDempsey CE, Roberts DL, Dive C. Bax, Bak and Bid: key mediators of apoptosis. In: Debatin KM, Fulda S, editors. Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts. Germany: Wiley-VCH Verlag GmbH; ...
Bik也能 [6] SuzukiM eta1.StructureofBax:coregulationofdimerformation 从Mcl一1/Bakl~llBc1.X./Bak复合物中置换出激活的 andintracellularlocalization.Ceit.2000 、03:645—654 Bak2【, 而且在没有Bim、Bid或缺少PUMA的细胞 [7] DewsonGeta1.BakactivationforapoptosiSinvoIves 中,Bax~llBak也可以促进凋亡...
Alterations in intracellular Ca 2+ homeostasis and cytochrome c release from mitochondria have been implicated in the regulation of apoptosis, but the relationship between these events remains unclear. Here we report that enforced expression of either Bax or Bak via adenoviral gene delivery results in...
Biotechnology and BioengineeringCost GJ, Freyvert Y, Vafiadis A, Santiago Y, Miller JC, Rebar E, Collingwood TN, Snowden A, Gregory PD. BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells. Biotechnol Bioeng, 2010, 105(2): 330-340....
Bax and Bak: back-bone of T cell death. Studies the function of the pro-apoptotic molecules, Bax and Bak in T cell development and homeostasis. Impact of apoptosis in shaping T cell development i... Bouillet,Philippe,Strasser,... - 《Nature Immunology》 被引量: 17发表: 2002年 Mechanisms...
Although activation of canonical intrinsic apoptosis is known to require pro-apoptotic Bcl-2 family proteins Bax and Bak, their individual and combined involvement in glucolipotoxic β-cell death are not known. It has also remained an open question if Bax and Bak in β-cells have non-apoptotic...