To define the mechanisms linking proliferation and apoptotic threshold, we examined the effect of conditionally deleting, the gene that codes the antiapoptotic protein BCL-xL, in cerebellar granule neuron progenitors (CGNPs), and of co-deletinghomologs, antiapoptotic, or pro-apoptotic. We found that...
Programmed cell death and Bcl-2 protection in the absence of a nucleus. The molecular basis of programmed cell death (PCD) is unknown. An important clue is provided by the Bcl-2 protein, which can protect many cell types from P... M,D,Jacobson,... - 《Embo Journal》 被引量: 1413发...
Here, we succeeded in engineering long-lived antigen-presenting DCs via Bcl-XL-derived hyperactive mutant antiapoptotic protein (Bcl-X FNK) gene transfer. In a B16BL6 melanoma model, these long-lived DCs exerted potent antitumor immunity that depended mainly on antigen-specific cytotoxic T ...
plasma). Bcl-2 may also have intrinsicantioxidant activity. Other proteins,IAPssuch asXIAP(X-linked) and NIAP (neuronal), can directly inhibitcaspases. Additional examples ofantiapoptoticproteins includeprotease inhibitorssuch ascalpastatin, andprotein chaperonessuch as GRP-78 andheat shock protein(HSP)...
171 Some inhibitors of the anti-apoptotic protein Bcl-xl (B-cell lymphoma–extra large) have been identified by 3D computational screenings of compound libraries.172 ABT-737 is one of the best-characterized BH3 mimetics, being able to reverse resistances by inhibiting anti-apoptotic proteins Bcl...
There was a link between the level of Bcl-2 protein and IC50. APG-1252-12A targeted mitochondria and induced caspase-dependent apoptosis by inducing the HL-60 cell cytochromec released, PARP cleavage and caspase activation. These data suggested that APG-1252-12A is a candidate drug for the ...
diagnostic chronic phase samples from patients with high and low CIP2A protein levels, high CIP2A levels correlate with an antiapoptotic phenotype, characterized by downregulation of proapoptotic BCL-2 family members, including BIM, PUMA and HRK, and upregulation of the antiapoptotic protein BCL-XL....
We report that cell death promoting activity of BH3-only protein Bim can be reconstituted in yeast when both Bax and antiapoptotic protein Bcl-XL are present, suggesting that Bim likely activates Bax indirectly by inhibiting antiapoptotic proteins. 展开 ...
protein,Bid,resultingintheapoptogenicactivationof SeveralmiRNAs(miR-146a/b,miR-132andmiR-155)were mitochondria.Therefore,theexecutionofapoptosiscanbe foundtobeupregulatedinresponsetolipopolysaccharide inhibitedbyoverexpressionofBcl-2orBcl-xLonlyintypeII (LPS)aswellastoothermicrobialcomponentsand30 cells.Division...
The antiapoptotic Bcl-2 family member Mcl-1 is a PEST protein (containing sequences enriched in proline, glutamic acid, serine, and threonine) and is subje... SK Nifoussi,JA Vrana,AM Domina,... - 《Plos One》 被引量: 207发表: 2012年 Delving Deeper: MCL-1's Contributions to Normal...